STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mvaShydroxymethylglutaryl-CoA synthase (HMG-CoA synthase). (399 aa)    
Predicted Functional Partners:
mvaA
3-hydroxy-3-methylglutaryl-coenzyme A reductase; Belongs to the HMG-CoA reductase family.
 
 0.999
mvaD
Mevalonate pyrophosphate decarboxylase.
 
 
 0.928
pfl
Pyruvate formate-lyase.
    
  0.904
idi
Isopentenyl diphosphate isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
 
  
 0.877
mvaK1
Mevalonate kinase.
 
  
 0.846
mvaK2
Phosphomevalonate kinase.
 
  
 0.842
gltA
Citrate synthase; Belongs to the citrate synthase family.
    
 0.827
acoC
Acetoin/pyruvate dehydrogenase complex, E2 component, dihydrolipoamide succinyltransferase.
   
 
  0.808
acpP2
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family.
  
 
 0.769
fabK
trans-2-enoyl-ACP reductase II.
  
  
 0.751
Your Current Organism:
Streptococcus thermophilus
NCBI taxonomy Id: 264199
Other names: S. thermophilus LMG 18311, Streptococcus thermophilus LMG 18311, Streptococcus thermophilus str. LMG 18311, Streptococcus thermophilus strain LMG 18311
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