STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (416 aa)    
Predicted Functional Partners:
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase (IMP cyclohydrolase).
  
 0.994
folD
Methylenetetrahydrofolate dehydrogenase / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
 
 0.989
fhs
Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.
  
 0.983
purL
Phosphoribosylformylglycinamidine synthase II (FGAM synthetase).
  
  
 0.973
purN
Phosphoribosylglycinamide (GAR) formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
  
 0.968
sdaA
L-serine dehydratase alpha subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family.
  
 
 0.963
acoL
Acetoin/pyruvate dehydrogenase complex, E3 component, dihydrolipoamide dehydrogenase.
  
 0.953
sdaB
L-serine dehydratase beta subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family.
  
 
 0.950
metF
5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
  
 
 0.943
serB
Phosphoserine phosphatase; Belongs to the HAD-like hydrolase superfamily. SerB family.
  
 0.940
Your Current Organism:
Streptococcus thermophilus
NCBI taxonomy Id: 264199
Other names: S. thermophilus LMG 18311, Streptococcus thermophilus LMG 18311, Streptococcus thermophilus str. LMG 18311, Streptococcus thermophilus strain LMG 18311
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