Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
sthIRDNA endonuclease, type III restriction and modification system. (928 aa)    
Predicted Functional Partners:
sthIM
Type III restriction-modification system methylation subunit.
 
     0.947
stu0183
Conserved hypothetical protein, putative protein kinase.
      
 0.622
bioY1
Biotin synthase.
      
 0.622
bioY2
Biotin synthase.
      
 0.622
stu1314
Hypothetical protein.
      
 0.622
hutU
Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate.
      
 0.622
stu0973
Truncated.
      
 0.621
stu0975
Amino acid ABC uptake transporter substrate binding protein, truncated; Truncated.
      
 0.621
stu1015
Maltose/maltodextrin ABC uptake transporter substrate-binding protein, truncated; Truncated.
      
 0.621
hutH
Histidine ammonia-lyase.
      
 0.589
Your Current Organism:
Streptococcus thermophilus
NCBI taxonomy Id: 264199
Other names: S. thermophilus LMG 18311, Streptococcus thermophilus LMG 18311, Streptococcus thermophilus str. LMG 18311, Streptococcus thermophilus strain LMG 18311
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