Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
rr04Response regulator (homolog to spaR Bsu & DvnR Cdi). (219 aa)    
Predicted Functional Partners:
hk04
Sensor histidine kinase (homolog to spaK Bsu).
 
 0.996
hk01
Sensor histidine kinase (homolog to csrS/covS Spy).
 
 
 0.870
stu0795
Sensor histidine kinase (homolog to ciaH Spn), truncated; Truncated.
 
 
 0.840
hk07
Sensor histidine kinase (homolog to HK01Spn & Sth).
 
 
 0.807
hk05
Sensor histidine kinase (homolog to HK02/MicB Spn & HK02 Sth & VicK Spy).
 
 
 0.801
stu0900
Conserved hypothetical, predicted membrane protein (TMS8).
       0.673
eep
Conserved hypothetical, predicted membrane protein (TMS5).
      
 0.639
stu0437
Sensor histidine kinase, uncoupled, truncated; Truncated.
 
 
 0.606
aroE
Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
     
 0.551
gid
Glucose-inhibited division protein; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily.
  
    0.526
Your Current Organism:
Streptococcus thermophilus
NCBI taxonomy Id: 264199
Other names: S. thermophilus LMG 18311, Streptococcus thermophilus LMG 18311, Streptococcus thermophilus str. LMG 18311, Streptococcus thermophilus strain LMG 18311
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