| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cysD | hom | stu0987 | stu0469 | O-acetylhomoserine sulfhydrylase. | Homoserine dehydrogenase. | 0.866 |
| cysD | ilvA | stu0987 | stu0150 | O-acetylhomoserine sulfhydrylase. | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.812 |
| cysD | metA | stu0987 | stu1222 | O-acetylhomoserine sulfhydrylase. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.963 |
| cysD | metB1 | stu0987 | stu0352 | O-acetylhomoserine sulfhydrylase. | Cystathionine gamma-synthase. | 0.932 |
| cysD | metE | stu0987 | stu0785 | O-acetylhomoserine sulfhydrylase. | 5-methyl tetrahydropteroyltriglutamate -- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.916 |
| cysD | thrB | stu0987 | stu0470 | O-acetylhomoserine sulfhydrylase. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.812 |
| hom | cysD | stu0469 | stu0987 | Homoserine dehydrogenase. | O-acetylhomoserine sulfhydrylase. | 0.866 |
| hom | ilvA | stu0469 | stu0150 | Homoserine dehydrogenase. | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.401 |
| hom | lysC | stu0469 | stu0378 | Homoserine dehydrogenase. | Aspartate kinase; Belongs to the aspartokinase family. | 0.924 |
| hom | metA | stu0469 | stu1222 | Homoserine dehydrogenase. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.947 |
| hom | metB1 | stu0469 | stu0352 | Homoserine dehydrogenase. | Cystathionine gamma-synthase. | 0.863 |
| hom | metE | stu0469 | stu0785 | Homoserine dehydrogenase. | 5-methyl tetrahydropteroyltriglutamate -- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.845 |
| hom | metF | stu0469 | stu0786 | Homoserine dehydrogenase. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.555 |
| hom | sdaB | stu0469 | stu1316 | Homoserine dehydrogenase. | L-serine dehydratase beta subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.806 |
| hom | thrB | stu0469 | stu0470 | Homoserine dehydrogenase. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.999 |
| ilvA | cysD | stu0150 | stu0987 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | O-acetylhomoserine sulfhydrylase. | 0.812 |
| ilvA | hom | stu0150 | stu0469 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Homoserine dehydrogenase. | 0.401 |
| ilvA | metA | stu0150 | stu1222 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.826 |
| ilvA | metB1 | stu0150 | stu0352 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Cystathionine gamma-synthase. | 0.833 |
| ilvA | metE | stu0150 | stu0785 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 5-methyl tetrahydropteroyltriglutamate -- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.826 |
