| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| apt | deoD | stu1223 | stu1113 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Purine nucleoside phosphorylase (family 1). | 0.911 |
| apt | gmk | stu1223 | stu1431 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.942 |
| apt | guaA | stu1223 | stu0886 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.982 |
| apt | guaB | stu1223 | stu2016 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.654 |
| apt | hpt | stu1223 | stu0011 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxantine-guanine phosphorybosyltransferase. | 0.978 |
| apt | punA | stu1223 | stu1117 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Purine nucleoside phosphorylase (family 2); The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.924 |
| apt | stu0979 | stu1223 | stu0979 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 5'-nucleotidase, putative; Belongs to the 5'-nucleotidase family. | 0.902 |
| apt | stu1338 | stu1223 | stu1338 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine phosphoribosyltransferase, truncated; Truncated. | 0.959 |
| deoD | apt | stu1113 | stu1223 | Purine nucleoside phosphorylase (family 1). | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.911 |
| deoD | hpt | stu1113 | stu0011 | Purine nucleoside phosphorylase (family 1). | Hypoxantine-guanine phosphorybosyltransferase. | 0.914 |
| deoD | punA | stu1113 | stu1117 | Purine nucleoside phosphorylase (family 1). | Purine nucleoside phosphorylase (family 2); The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.930 |
| deoD | stu0979 | stu1113 | stu0979 | Purine nucleoside phosphorylase (family 1). | 5'-nucleotidase, putative; Belongs to the 5'-nucleotidase family. | 0.901 |
| deoD | stu1338 | stu1113 | stu1338 | Purine nucleoside phosphorylase (family 1). | Xanthine phosphoribosyltransferase, truncated; Truncated. | 0.910 |
| gmk | apt | stu1431 | stu1223 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.942 |
| gmk | guaA | stu1431 | stu0886 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.958 |
| gmk | guaB | stu1431 | stu2016 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Inosine monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.465 |
| gmk | hpt | stu1431 | stu0011 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Hypoxantine-guanine phosphorybosyltransferase. | 0.924 |
| gmk | stu0979 | stu1431 | stu0979 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 5'-nucleotidase, putative; Belongs to the 5'-nucleotidase family. | 0.900 |
| gmk | stu1338 | stu1431 | stu1338 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Xanthine phosphoribosyltransferase, truncated; Truncated. | 0.941 |
| guaA | apt | stu0886 | stu1223 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.982 |