stu1459 protein (Streptococcus thermophilus)

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Score

stu1459

GTP pyrophosphokinase, putative. (241 aa)

Predicted Functional Partners:

relA

0.933

ndk

0.900

nrdD

0.900

ppnK

0.898

stu1456

0.860

pta

0.850

folE

0.800

stu1458

0.780

stu1454

0.667

prsA2

0.605

Your Current Organism:

Streptococcus thermophilus

NCBI taxonomy Id: 264199
Other names: S. thermophilus LMG 18311, Streptococcus thermophilus LMG 18311, Streptococcus thermophilus str. LMG 18311, Streptococcus thermophilus strain LMG 18311

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
folE	ndk	stu1544	stu0906	GTP cyclohydrolase I.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.841
folE	nrdD	stu1544	stu1963	GTP cyclohydrolase I.	Anaerobic ribonucleoside-triphosphate reductase.	0.800
folE	relA	stu1544	stu0145	GTP cyclohydrolase I.	(p)ppGpp synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	0.800
folE	stu1459	stu1544	stu1459	GTP cyclohydrolase I.	GTP pyrophosphokinase, putative.	0.800
ndk	folE	stu0906	stu1544	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	GTP cyclohydrolase I.	0.841
ndk	nrdD	stu0906	stu1963	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	Anaerobic ribonucleoside-triphosphate reductase.	0.906
ndk	relA	stu0906	stu0145	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	(p)ppGpp synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	0.915
ndk	stu1459	stu0906	stu1459	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	GTP pyrophosphokinase, putative.	0.900
nrdD	folE	stu1963	stu1544	Anaerobic ribonucleoside-triphosphate reductase.	GTP cyclohydrolase I.	0.800
nrdD	ndk	stu1963	stu0906	Anaerobic ribonucleoside-triphosphate reductase.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.906
nrdD	relA	stu1963	stu0145	Anaerobic ribonucleoside-triphosphate reductase.	(p)ppGpp synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	0.909
nrdD	stu1459	stu1963	stu1459	Anaerobic ribonucleoside-triphosphate reductase.	GTP pyrophosphokinase, putative.	0.900
ppnK	prsA2	stu1457	stu1460	ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.	0.634
ppnK	pta	stu1457	stu1455	ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	Phosphotransacetylase.	0.943
ppnK	stu1454	stu1457	stu1454	ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	IS861, transposase (orf1), IS3 family, truncated; Truncated.	0.667
ppnK	stu1456	stu1457	stu1456	ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	Ribosomal large subunit pseudouridine synthase, RluD subfamily; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.	0.875
ppnK	stu1458	stu1457	stu1458	ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	Conserved hypothetical protein.	0.793
ppnK	stu1459	stu1457	stu1459	ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	GTP pyrophosphokinase, putative.	0.898
prsA2	ppnK	stu1460	stu1457	Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.	ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.634
prsA2	pta	stu1460	stu1455	Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.	Phosphotransacetylase.	0.657

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