node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
folA | folC1 | stu0579 | stu0409 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Folylpolyglutamate synthase / dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | 0.974 |
folA | folC2 | stu0579 | stu1546 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Folylpolyglutamate synthase / dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | 0.964 |
folA | folE | stu0579 | stu1544 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | GTP cyclohydrolase I. | 0.831 |
folA | folK | stu0579 | stu1540 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Hydroxymethylpterin pyrophosphokinase. | 0.848 |
folA | folP | stu0579 | stu1543 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.852 |
folA | folQ | stu0579 | stu1541 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.813 |
folC1 | folA | stu0409 | stu0579 | Folylpolyglutamate synthase / dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.974 |
folC1 | folC2 | stu0409 | stu1546 | Folylpolyglutamate synthase / dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | Folylpolyglutamate synthase / dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | 0.915 |
folC1 | folE | stu0409 | stu1544 | Folylpolyglutamate synthase / dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | GTP cyclohydrolase I. | 0.852 |
folC1 | folK | stu0409 | stu1540 | Folylpolyglutamate synthase / dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | Hydroxymethylpterin pyrophosphokinase. | 0.857 |
folC1 | folP | stu0409 | stu1543 | Folylpolyglutamate synthase / dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.998 |
folC1 | folQ | stu0409 | stu1541 | Folylpolyglutamate synthase / dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.431 |
folC2 | folA | stu1546 | stu0579 | Folylpolyglutamate synthase / dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.964 |
folC2 | folC1 | stu1546 | stu0409 | Folylpolyglutamate synthase / dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | Folylpolyglutamate synthase / dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | 0.915 |
folC2 | folE | stu1546 | stu1544 | Folylpolyglutamate synthase / dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | GTP cyclohydrolase I. | 0.891 |
folC2 | folK | stu1546 | stu1540 | Folylpolyglutamate synthase / dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | Hydroxymethylpterin pyrophosphokinase. | 0.887 |
folC2 | folP | stu1546 | stu1543 | Folylpolyglutamate synthase / dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.999 |
folC2 | folQ | stu1546 | stu1541 | Folylpolyglutamate synthase / dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.431 |
folE | folA | stu1544 | stu0579 | GTP cyclohydrolase I. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.831 |
folE | folC1 | stu1544 | stu0409 | GTP cyclohydrolase I. | Folylpolyglutamate synthase / dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | 0.852 |