STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pflAPyruvate-formate lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (266 aa)    
Predicted Functional Partners:
pfl
Pyruvate formate-lyase.
  
 0.989
adhB
Alcohol dehydrogenase, zinc-containing.
   
  
 0.749
stu1882
Alcohol-acetaldehyde dehydrogenase, truncated; Truncated.
  
  
 0.721
stu1883
Alcohol-acetaldehyde dehydrogenase, truncated; Truncated.
  
  
 0.721
pta
Phosphotransacetylase.
     
 0.621
ackA
Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
     
 0.580
stu1639
Unknown protein.
       0.472
acoB
Acetoin dehydrogenase complex, E1 component, beta subunit.
   
  
 0.465
acoL
Acetoin/pyruvate dehydrogenase complex, E3 component, dihydrolipoamide dehydrogenase.
  
  
 0.458
acoA
Acetoin dehydrogenase complex, E1 component, alpha subunit.
   
  
 0.445
Your Current Organism:
Streptococcus thermophilus
NCBI taxonomy Id: 264199
Other names: S. thermophilus LMG 18311, Streptococcus thermophilus LMG 18311, Streptococcus thermophilus str. LMG 18311, Streptococcus thermophilus strain LMG 18311
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.