| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cmk | comEB | stu1135 | stu1741 | Cytidylate kinase. | Late competence protein required for DNA binding and uptake. | 0.903 |
| cmk | stu0979 | stu1135 | stu0979 | Cytidylate kinase. | 5'-nucleotidase, putative; Belongs to the 5'-nucleotidase family. | 0.900 |
| comEB | cmk | stu1741 | stu1135 | Late competence protein required for DNA binding and uptake. | Cytidylate kinase. | 0.903 |
| comEB | dut | stu1741 | stu1824 | Late competence protein required for DNA binding and uptake. | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.946 |
| comEB | efp | stu1741 | stu1740 | Late competence protein required for DNA binding and uptake. | Translation elongation factor EF-P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. | 0.571 |
| comEB | nusB | stu1741 | stu1738 | Late competence protein required for DNA binding and uptake. | Transcriptional termination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.525 |
| comEB | pepP | stu1741 | stu1742 | Late competence protein required for DNA binding and uptake. | Aminopeptidase P; XAA-pro aminopeptidase; Belongs to the peptidase M24B family. | 0.896 |
| comEB | stu0979 | stu1741 | stu0979 | Late competence protein required for DNA binding and uptake. | 5'-nucleotidase, putative; Belongs to the 5'-nucleotidase family. | 0.904 |
| comEB | stu1739 | stu1741 | stu1739 | Late competence protein required for DNA binding and uptake. | Conserved hypothetical protein. | 0.522 |
| comEB | tdk | stu1741 | stu0751 | Late competence protein required for DNA binding and uptake. | Thymidine kinase. | 0.927 |
| comEB | thyA | stu1741 | stu0578 | Late competence protein required for DNA binding and uptake. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.938 |
| comEB | tmk | stu1741 | stu0489 | Late competence protein required for DNA binding and uptake. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.932 |
| dut | comEB | stu1824 | stu1741 | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Late competence protein required for DNA binding and uptake. | 0.946 |
| dut | stu0979 | stu1824 | stu0979 | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 5'-nucleotidase, putative; Belongs to the 5'-nucleotidase family. | 0.900 |
| dut | tdk | stu1824 | stu0751 | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidine kinase. | 0.962 |
| dut | thyA | stu1824 | stu0578 | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.968 |
| dut | tmk | stu1824 | stu0489 | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.941 |
| efp | comEB | stu1740 | stu1741 | Translation elongation factor EF-P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. | Late competence protein required for DNA binding and uptake. | 0.571 |
| efp | nusB | stu1740 | stu1738 | Translation elongation factor EF-P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. | Transcriptional termination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.806 |
| efp | pepP | stu1740 | stu1742 | Translation elongation factor EF-P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. | Aminopeptidase P; XAA-pro aminopeptidase; Belongs to the peptidase M24B family. | 0.709 |