purR protein (Streptococcus thermophilus) - STRING interaction network

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purR

Purine operon repressor. (274 aa)

Predicted Functional Partners:

pyrH

0.820

guaA

0.770

relA

0.737

pyrB

0.722

purL

0.719

stu1796

0.656

codY

0.640

gcaD

0.622

rpe

0.622

punA

0.620

Your Current Organism:

Streptococcus thermophilus

NCBI taxonomy Id: 264199
Other names: S. thermophilus LMG 18311, Streptococcus thermophilus LMG 18311, Streptococcus thermophilus str. LMG 18311, Streptococcus thermophilus strain LMG 18311

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
codY	purR	stu1635	stu1793	Transcriptional pleiotropic repressor; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family.	Purine operon repressor.	0.640
gcaD	purR	stu0563	stu1793	UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family.	Purine operon repressor.	0.622
gcaD	pyrH	stu0563	stu0438	UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family.	Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.	0.429
guaA	punA	stu0886	stu1117	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Purine nucleoside phosphorylase (family 2); The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.588
guaA	purL	stu0886	stu0031	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Phosphoribosylformylglycinamidine synthase II (FGAM synthetase).	0.987
guaA	purR	stu0886	stu1793	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Purine operon repressor.	0.770
guaA	pyrB	stu0886	stu0525	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Aspartate transcarbamoylase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.	0.641
guaA	pyrH	stu0886	stu0438	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.	0.655
guaA	rpe	stu0886	stu1797	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family.	0.481
punA	guaA	stu1117	stu0886	Purine nucleoside phosphorylase (family 2); The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.588
punA	purR	stu1117	stu1793	Purine nucleoside phosphorylase (family 2); The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	Purine operon repressor.	0.620
purL	guaA	stu0031	stu0886	Phosphoribosylformylglycinamidine synthase II (FGAM synthetase).	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.987
purL	purR	stu0031	stu1793	Phosphoribosylformylglycinamidine synthase II (FGAM synthetase).	Purine operon repressor.	0.719
purL	pyrB	stu0031	stu0525	Phosphoribosylformylglycinamidine synthase II (FGAM synthetase).	Aspartate transcarbamoylase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.	0.705
purL	pyrH	stu0031	stu0438	Phosphoribosylformylglycinamidine synthase II (FGAM synthetase).	Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.	0.496
purL	rpe	stu0031	stu1797	Phosphoribosylformylglycinamidine synthase II (FGAM synthetase).	Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family.	0.401
purR	codY	stu1793	stu1635	Purine operon repressor.	Transcriptional pleiotropic repressor; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family.	0.640
purR	gcaD	stu1793	stu0563	Purine operon repressor.	UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family.	0.622
purR	guaA	stu1793	stu0886	Purine operon repressor.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.770
purR	punA	stu1793	stu1117	Purine operon repressor.	Purine nucleoside phosphorylase (family 2); The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.620

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