STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemAPutative glutamyl tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (340 aa)    
Predicted Functional Partners:
hemC
Putative Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.998
hemL
Strongly similar to glutamate-1-semialdehyde 2,1-aminomutase.
 
 0.991
gltX
Probable glutamate-tRNA ligase (= glutamyl-tRNA synthetase); Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
     
 0.930
hemB
Strongly similar to porphobilinogen synthase (delta-aminolevulinic acid dehydratase, (ALAD)), hemB; Belongs to the ALAD family.
 
  
 0.875
hemE
Probable uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
  
 0.613
pc1580
Hypothetical protein.
     
 0.590
pc0271
Conserved hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
  
 0.497
pc1094
Hypothetical protein.
  
  
 0.473
ribD
Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
   
  
 0.456
hemH
Putative ferrochelatase (heme synthetase), hemH; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
  
  
 0.443
Your Current Organism:
Protochlamydia amoebophila
NCBI taxonomy Id: 264201
Other names: C. Protochlamydia amoebophila UWE25, Candidatus Protochlamydia amoebophila UWE25, Candidatus Protochlamydia amoebophila str. UWE25, Candidatus Protochlamydia amoebophila strain UWE25, Parachlamydia sp. UWE25, Parachlamydia-related symbiont UWE25, endosymbiont of Acanthamoeba sp. UWE25
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.