STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pc1124Similar to calcium-dependent protein kinase 9. (464 aa)    
Predicted Functional Partners:
recA
Probable recombination protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.959
pc0720
Similar to serine/threonine phosphoprotein phosphatase.
 
 
 0.895
polA
Probable DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 
 0.794
pkn
Similar to serine/threonine protein kinase.
 
  
 0.779
dnaN
Putative DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initia [...]
  
 
 0.734
pknD
Conserved hypothetical protein; Together with the serine/threonine kinase Pkn1, may play a role in the specific interactions with host proteins during intracellular growth.
  
    0.733
pc1080
Conserved hypothetical protein.
 
  
 0.729
ptc1
Similar to phosphoprotein phosphatase.
 
 
 0.717
dnlJ
Probable DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
  
  
 0.704
rpoB
Probable DNA-directed RNA polymerase, beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.697
Your Current Organism:
Protochlamydia amoebophila
NCBI taxonomy Id: 264201
Other names: C. Protochlamydia amoebophila UWE25, Candidatus Protochlamydia amoebophila UWE25, Candidatus Protochlamydia amoebophila str. UWE25, Candidatus Protochlamydia amoebophila strain UWE25, Parachlamydia sp. UWE25, Parachlamydia-related symbiont UWE25, endosymbiont of Acanthamoeba sp. UWE25
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