STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (484 aa)    
Predicted Functional Partners:
leuD
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 0.999
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
 0.999
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.993
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
 
 
 0.978
ZMO1835
KEGG: gdj:Gdia_1557 homocitrate synthase; TIGRFAM: homocitrate synthase; PFAM: pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 0.960
ZMO1140
KEGG: swi:Swit_0610 acetolactate synthase 3 regulatory subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; acetolactate synthase small subunit.
  
  
 0.914
ilvD
TIGRFAM: dihydroxy-acid dehydratase; KEGG: gbe:GbCGDNIH1_1938 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family.
  
  
 0.863
ZMO1570
TIGRFAM: formate acetyltransferase; KEGG: rpc:RPC_1080 formate acetyltransferase; PFAM: formate C-acetyltransferase glycine radical; pyruvate formate-lyase PFL.
     
 0.818
ZMO0152
TIGRFAM: pyruvate kinase; KEGG: swi:Swit_3121 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family.
    
 0.808
ddh
PFAM: D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: npu:Npun_F2517 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding.
     
 0.802
Your Current Organism:
Zymomonas mobilis ZM4
NCBI taxonomy Id: 264203
Other names: Z. mobilis subsp. mobilis ZM4 = ATCC 31821, Zymomonas mobilis subsp. mobilis ATCC 31821, Zymomonas mobilis subsp. mobilis ATCC 31821 = ZM4, Zymomonas mobilis subsp. mobilis ZM4, Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.