node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ZMO0663 | ispE | ZMO0663 | ZMO1182 | PFAM: DNA repair protein RadC; KEGG: swi:Swit_4476 DNA repair protein RadC; Belongs to the UPF0758 family. | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.616 |
ZMO0855 | ZMO1184 | ZMO0855 | ZMO1184 | PFAM: Polyprenyl synthetase; KEGG: nar:Saro_2253 farnesyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Electron-transferring-flavoprotein dehydrogenase; Accepts electrons from ETF and reduces ubiquinone. | 0.546 |
ZMO0855 | dxr | ZMO0855 | ZMO1150 | PFAM: Polyprenyl synthetase; KEGG: nar:Saro_2253 farnesyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 0.547 |
ZMO0855 | dxs1 | ZMO0855 | ZMO1234 | PFAM: Polyprenyl synthetase; KEGG: nar:Saro_2253 farnesyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 0.669 |
ZMO0855 | dxs2 | ZMO0855 | ZMO1598 | PFAM: Polyprenyl synthetase; KEGG: nar:Saro_2253 farnesyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 0.674 |
ZMO0855 | ispDF | ZMO0855 | ZMO1128 | PFAM: Polyprenyl synthetase; KEGG: nar:Saro_2253 farnesyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | 0.555 |
ZMO0855 | ispE | ZMO0855 | ZMO1182 | PFAM: Polyprenyl synthetase; KEGG: nar:Saro_2253 farnesyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.592 |
ZMO0855 | ispG | ZMO0855 | ZMO0180 | PFAM: Polyprenyl synthetase; KEGG: nar:Saro_2253 farnesyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. | 0.572 |
ZMO0855 | ispH | ZMO0855 | ZMO0875 | PFAM: Polyprenyl synthetase; KEGG: nar:Saro_2253 farnesyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.944 |
ZMO1181 | ispE | ZMO1181 | ZMO1182 | PFAM: N-formylglutamate amidohydrolase; KEGG: swi:Swit_4642 N-formylglutamate amidohydrolase. | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.583 |
ZMO1184 | ZMO0855 | ZMO1184 | ZMO0855 | Electron-transferring-flavoprotein dehydrogenase; Accepts electrons from ETF and reduces ubiquinone. | PFAM: Polyprenyl synthetase; KEGG: nar:Saro_2253 farnesyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 0.546 |
ZMO1184 | ispDF | ZMO1184 | ZMO1128 | Electron-transferring-flavoprotein dehydrogenase; Accepts electrons from ETF and reduces ubiquinone. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | 0.404 |
ZMO1184 | ispE | ZMO1184 | ZMO1182 | Electron-transferring-flavoprotein dehydrogenase; Accepts electrons from ETF and reduces ubiquinone. | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.588 |
dxr | ZMO0855 | ZMO1150 | ZMO0855 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | PFAM: Polyprenyl synthetase; KEGG: nar:Saro_2253 farnesyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 0.547 |
dxr | dxs1 | ZMO1150 | ZMO1234 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 0.971 |
dxr | dxs2 | ZMO1150 | ZMO1598 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 0.955 |
dxr | ispDF | ZMO1150 | ZMO1128 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | 0.991 |
dxr | ispE | ZMO1150 | ZMO1182 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.939 |
dxr | ispG | ZMO1150 | ZMO0180 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. | 0.942 |
dxr | ispH | ZMO1150 | ZMO0875 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.954 |