STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PRU_0004Putative lipoprotein. (661 aa)    
Predicted Functional Partners:
PRU_0003
Identified by match to protein family HMM PF00691.
  
  
 0.688
PRU_0002
Hypothetical protein; Identified by glimmer; putative.
       0.503
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.481
PRU_2475
Type II topoisomerase family protein; Identified by match to protein family HMM PF00204; match to protein family HMM PF01751; match to protein family HMM PF02518.
   
 
 0.481
PRU_0008
Topoisomerase gyrA/parC subunit family protein; Identified by match to protein family HMM PF00521.
  
  
 0.438
Your Current Organism:
Prevotella ruminicola
NCBI taxonomy Id: 264731
Other names: P. ruminicola 23, Prevotella ruminicola 23, Prevotella ruminicola Bryant 23, Prevotella ruminicola str. 23, Prevotella ruminicola strain 23
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.