STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. (353 aa)    
Predicted Functional Partners:
leuC
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 0.999
leuD
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
 
 0.999
ilvN
Acetolactate synthase, small subunit; Identified by similarity to SP:P37252; match to protein family HMM PF01842; match to protein family HMM TIGR00119.
 
 0.989
ilvB
Acetolactate synthase, large subunit, biosynthetic type; Identified by similarity to GB:AAL99356.1; match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR00118.
 
 0.980
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 
 0.964
PRU_0732
(R)-citramalate synthase; Identified by similarity to SP:Q58787; match to protein family HMM PF00682; match to protein family HMM PF08502; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 
 0.961
PRU_0734
Tetratricopeptide repeat protein; Identified by match to protein family HMM PF00515; match to protein family HMM PF07719.
   
 
 0.803
PRU_1719
Putative proton-translocating NADH-quinone oxidoreductase, D subunit; Identified by match to protein family HMM PF00329; match to protein family HMM PF00346.
  
 0.786
ilvC
Ketol-acid reductoisomerase; Identified by match to protein family HMM PF01450; match to protein family HMM PF07991; match to protein family HMM TIGR00465.
 
  
 0.771
thrA
Aspartate kinase/homoserine dehydrogenase; Identified by similarity to SP:P00561; match to protein family HMM PF00696; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447; match to protein family HMM TIGR00657.
 
  
 0.748
Your Current Organism:
Prevotella ruminicola
NCBI taxonomy Id: 264731
Other names: P. ruminicola 23, Prevotella ruminicola 23, Prevotella ruminicola Bryant 23, Prevotella ruminicola str. 23, Prevotella ruminicola strain 23
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.