Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pfpDiphosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (545 aa)    
Predicted Functional Partners:
pgi
Glucose-6-phosphate isomerase; Identified by similarity to SP:P80860; match to protein family HMM PF00342; Belongs to the GPI family.
  
 0.963
fba
Fructose-1,6-bisphosphate aldolase, class II; Identified by match to protein family HMM PF01116; match to protein family HMM TIGR00167; match to protein family HMM TIGR01859.
  
 
 0.932
PRU_0393
Putative transketolase; Identified by similarity to SP:P45694; match to protein family HMM PF00456; match to protein family HMM PF02779; match to protein family HMM PF02780; Belongs to the transketolase family.
  
 0.924
PRU_2638
Kinase, pfkB family; Identified by match to protein family HMM PF00294.
 
 0.924
PRU_2278
Putative fructokinase; Identified by similarity to SP:P26984; match to protein family HMM PF00294.
  
 0.913
fbp
Fructose-1,6-bisphosphatase; Identified by similarity to GB:CAB16056.1; match to protein family HMM PF06874.
     
 0.910
manA
Mannose-6-phosphate isomerase, class I; Identified by similarity to SP:P39841; match to protein family HMM PF01238; match to protein family HMM TIGR00218.
    
 0.908
pfkA
6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
  
  
 
0.904
pyk
Pyruvate kinase; Identified by similarity to SP:P14178; match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family.
  
 
 0.788
PRU_0793
Glycosyl hydrolase, family 25 protein; Identified by match to protein family HMM PF01183.
       0.660
Your Current Organism:
Prevotella ruminicola
NCBI taxonomy Id: 264731
Other names: P. ruminicola 23, Prevotella ruminicola 23, Prevotella ruminicola Bryant 23, Prevotella ruminicola str. 23, Prevotella ruminicola strain 23
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