STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Moth_0605Putative signal-transduction protein with CBS domains. (211 aa)    
Predicted Functional Partners:
Moth_0606
Protein of unknown function DUF299; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.
 
  
 0.965
Moth_0064
Pyruvate:ferredoxin (flavodoxin) oxidoreductase; Catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA and carbon dioxide. The two electrons that are generated as a result of pyruvate decarboxylation are used in the reduction of low potential ferredoxins, which provide reducing equivalents for central metabolism. Also catalyzes the reverse reaction, i.e. the synthesis of pyruvate from acetyl-CoA and carbon dioxide. Appears to function physiologically in both directions. The oxidation of pyruvate by PFOR is required to connect glycolysis and the Wood- Ljungdahl pathway of re [...]
  
 
  0.922
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
    
 0.887
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
 0.878
Moth_0611
Tagatose-6-phosphate kinase; Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
  
 
 0.850
Moth_0607
Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family.
 
 
 0.819
Moth_1949
FAD dependent oxidoreductase.
  
 
 0.817
Moth_0012
Fructose-1-phosphate kinase; Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
  
 
 0.803
Moth_0262
Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
    
 0.800
Moth_2392
Ribose-5-phosphate isomerase.
  
 
 0.783
Your Current Organism:
Moorella thermoacetica
NCBI taxonomy Id: 264732
Other names: M. thermoacetica ATCC 39073, Moorella thermoacetica ATCC 39073, Moorella thermoacetica str. ATCC 39073, Moorella thermoacetica strain ATCC 39073
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.