Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Moth_1024Iron-containing alcohol dehydrogenase. (366 aa)    
Predicted Functional Partners:
Moth_0064
Pyruvate:ferredoxin (flavodoxin) oxidoreductase; Catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA and carbon dioxide. The two electrons that are generated as a result of pyruvate decarboxylation are used in the reduction of low potential ferredoxins, which provide reducing equivalents for central metabolism. Also catalyzes the reverse reaction, i.e. the synthesis of pyruvate from acetyl-CoA and carbon dioxide. Appears to function physiologically in both directions. The oxidation of pyruvate by PFOR is required to connect glycolysis and the Wood- Ljungdahl pathway of re [...]
  
 
 0.939
Moth_1949
FAD dependent oxidoreductase.
  
 
 0.824
Moth_1525
acetyl-CoA carboxylase, biotin carboxyl carrier protein.
    
 0.793
Moth_1718
NAD(P)-dependent iron-only hydrogenase diaphorase component flavoprotein.
  
 
 0.766
Moth_1887
NADH dehydrogenase (quinone).
  
 
 0.766
Moth_2314
Respiratory-chain NADH dehydrogenase, 51 kDa subunit.
  
 
 0.740
Moth_0464
Glycerol 2-dehydrogenase (NAD+).
 
  
 0.736
Moth_1593
2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate; Catalyzes the anaerobic oxidation of oxalate using a broad range of electron acceptors, including ferredoxin and the nickel- dependent carbon monoxide dehydrogenase. Does not require coenzyme A as cosubstrate. Enables anaerobic growth on oxalate which is used as energy source by the bacteria.
  
 
 0.726
Moth_2294
Radical SAM.
 
 
 0.668
glgA
Glycogen synthase (ADP-glucose); Synthesizes alpha-1,4-glucan chains using ADP-glucose.
   
    0.642
Your Current Organism:
Moorella thermoacetica
NCBI taxonomy Id: 264732
Other names: M. thermoacetica ATCC 39073, Moorella thermoacetica ATCC 39073, Moorella thermoacetica str. ATCC 39073, Moorella thermoacetica strain ATCC 39073
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