STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Moth_1488ATP dependent DNA ligase, central. (320 aa)    
Predicted Functional Partners:
Moth_0003
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.994
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
 0.992
Moth_2067
Conserved hypothetical protein.
  
 0.992
Moth_2082
Conserved hypothetical protein.
  
 0.992
ku
DNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.977
Moth_1748
PHP-like protein.
  
 0.974
Moth_0043
DNA-directed DNA polymerase.
   
 0.964
Moth_0972
Signal peptidase I, Serine peptidase, MEROPS family S26A; Belongs to the peptidase S26 family.
    
 0.909
Moth_1788
ATPase involved in DNA repair-like protein.
   
 0.901
dinG
DNA polymerase III, epsilon subunit; 3'-5' exonuclease.
   
 
 0.897
Your Current Organism:
Moorella thermoacetica
NCBI taxonomy Id: 264732
Other names: M. thermoacetica ATCC 39073, Moorella thermoacetica ATCC 39073, Moorella thermoacetica str. ATCC 39073, Moorella thermoacetica strain ATCC 39073
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.