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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Moth_2277Thiamine pyrophosphate enzyme; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (631 aa)    
Predicted Functional Partners:
Moth_2276
Pyruvate ferredoxin/flavodoxin oxidoreductase.
 
 0.987
Moth_0064
Pyruvate:ferredoxin (flavodoxin) oxidoreductase; Catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA and carbon dioxide. The two electrons that are generated as a result of pyruvate decarboxylation are used in the reduction of low potential ferredoxins, which provide reducing equivalents for central metabolism. Also catalyzes the reverse reaction, i.e. the synthesis of pyruvate from acetyl-CoA and carbon dioxide. Appears to function physiologically in both directions. The oxidation of pyruvate by PFOR is required to connect glycolysis and the Wood- Ljungdahl pathway of re [...]
  
 0.981
Moth_0934
Pyruvate ferredoxin/flavodoxin oxidoreductase.
 0.941
Moth_1887
NADH dehydrogenase (quinone).
    
 0.940
Moth_1718
NAD(P)-dependent iron-only hydrogenase diaphorase component flavoprotein.
    
 0.917
Moth_2138
Hypothetical protein.
  
 0.905
Moth_1593
2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate; Catalyzes the anaerobic oxidation of oxalate using a broad range of electron acceptors, including ferredoxin and the nickel- dependent carbon monoxide dehydrogenase. Does not require coenzyme A as cosubstrate. Enables anaerobic growth on oxalate which is used as energy source by the bacteria.
  
 0.809
Moth_1949
FAD dependent oxidoreductase.
 
 
 0.800
Moth_1867
Pyruvate kinase; Belongs to the pyruvate kinase family.
     
 0.799
Moth_2314
Respiratory-chain NADH dehydrogenase, 51 kDa subunit.
 
 
 0.716
Your Current Organism:
Moorella thermoacetica
NCBI taxonomy Id: 264732
Other names: M. thermoacetica ATCC 39073, Moorella thermoacetica ATCC 39073, Moorella thermoacetica str. ATCC 39073, Moorella thermoacetica strain ATCC 39073
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