A0A443I4Q3 protein (Byssochlamys spectabilis)

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

A0A443I4Q3

D-isomer-specific 2-hydroxyacid dehydrogenase family protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (348 aa)

Predicted Functional Partners:

A0A443HYP2

0.966

A0A443HTM6

0.917

A0A443I2V9

0.895

A0A443HHF8

0.853

A0A443HRN2

0.810

A0A443HTS8

0.810

A0A443HTT5

0.810

A0A443I7T6

0.810

A0A443I4G8

0.792

A0A443I6N0

0.789

Your Current Organism:

Byssochlamys spectabilis

NCBI taxonomy Id: 264951
Other names: ATCC 90900, B. spectabilis, Byssochlamys spectabilis (Udagawa & Shoji Suzuki) Houbraken & Samson 2008, CBS 101075, FRR 5219, JCM 12815, Pacilomyces variotii, Paecilomyces spectabilis, Paecilomyces variotii, Paecilomyces variotti, Paecilomyces vatiotii, Talaromyces spectabilis

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A443HHF8	A0A443I4Q3	Uncharacterized protein.	D-isomer-specific 2-hydroxyacid dehydrogenase family protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.853
A0A443HRN2	A0A443HTM6	Uncharacterized protein.	Tryptophan synthase.	0.734
A0A443HRN2	A0A443I4G8	Uncharacterized protein.	HAD-like domain-containing protein.	0.828
A0A443HRN2	A0A443I4Q3	Uncharacterized protein.	D-isomer-specific 2-hydroxyacid dehydrogenase family protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.810
A0A443HRN2	A0A443I6N0	Uncharacterized protein.	Aminotransferase.	0.671
A0A443HTM6	A0A443HRN2	Tryptophan synthase.	Uncharacterized protein.	0.734
A0A443HTM6	A0A443HTS8	Tryptophan synthase.	Uncharacterized protein.	0.734
A0A443HTM6	A0A443HTT5	Tryptophan synthase.	Uncharacterized protein.	0.734
A0A443HTM6	A0A443HYP2	Tryptophan synthase.	Pyridoxal phosphate-dependent transferase.	0.734
A0A443HTM6	A0A443I4G8	Tryptophan synthase.	HAD-like domain-containing protein.	0.963
A0A443HTM6	A0A443I4Q3	Tryptophan synthase.	D-isomer-specific 2-hydroxyacid dehydrogenase family protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.917
A0A443HTM6	A0A443I6N0	Tryptophan synthase.	Aminotransferase.	0.942
A0A443HTM6	A0A443I7T6	Tryptophan synthase.	Uncharacterized protein.	0.734
A0A443HTS8	A0A443HTM6	Uncharacterized protein.	Tryptophan synthase.	0.734
A0A443HTS8	A0A443I4G8	Uncharacterized protein.	HAD-like domain-containing protein.	0.828
A0A443HTS8	A0A443I4Q3	Uncharacterized protein.	D-isomer-specific 2-hydroxyacid dehydrogenase family protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.810
A0A443HTS8	A0A443I6N0	Uncharacterized protein.	Aminotransferase.	0.671
A0A443HTT5	A0A443HTM6	Uncharacterized protein.	Tryptophan synthase.	0.734
A0A443HTT5	A0A443I4G8	Uncharacterized protein.	HAD-like domain-containing protein.	0.828
A0A443HTT5	A0A443I4Q3	Uncharacterized protein.	D-isomer-specific 2-hydroxyacid dehydrogenase family protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.810

page 1 of 3

Network Stats

number of nodes:

4

number of edges:

5

average node degree:

2.5

avg. local clustering coefficient:

0.833

expected number of edges:

3

PPI enrichment p-value:

0.157

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016226

Iron-sulfur cluster assembly

9 of 32

2.51

8.28

3.24e-18

GO:0006790

Sulfur compound metabolic process

10 of 173

1.82

4.68

4.40e-15

GO:0006783

Heme biosynthetic process

4 of 18

2.4

3.04

1.40e-06

GO:0018283

Iron incorporation into metallo-sulfur cluster

3 of 3

3.06

3.03

3.02e-06

GO:0006879

Cellular iron ion homeostasis

4 of 35

2.12

2.56

6.67e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051536

Iron-sulfur cluster binding

8 of 71

2.11

5.24

4.47e-13

GO:0051537

2 iron, 2 sulfur cluster binding

6 of 29

2.37

4.96

7.35e-11

GO:0008198

Ferrous iron binding

4 of 13

2.55

3.48

2.44e-07

GO:0005506

Iron ion binding

8 of 205

1.65

3.1

3.83e-10

GO:0004322

Ferroxidase activity

3 of 3

3.06

3.1

2.31e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005759

Mitochondrial matrix

6 of 200

1.53

2.01

3.29e-06

GO:1990221

L-cysteine desulfurase complex

2 of 3

2.88

1.49

0.0020

GO:0005739

Mitochondrion

10 of 985

1.06

1.32

8.01e-08

GO:0043231

Intracellular membrane-bounded organelle

11 of 4720

0.42

0.34

0.0045

GO:0005737

Cytoplasm

11 of 4847

0.41

0.33

0.0045

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15154

Mitochondrial iron-sulfur cluster biogenesis, and Aminotransferase class V domain

10 of 20

2.76

11.17

2.49e-23

CL:15155

Mitochondrial iron-sulfur cluster biogenesis

7 of 11

2.86

8.09

3.11e-16

CL:15158

Mitochondrial iron-sulfur cluster biogenesis

4 of 5

2.96

4.34

1.02e-08

CL:15178

HesB-like domain superfamily, and [2Fe-2S] cluster assembly

2 of 5

2.66

1.36

0.0033

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00195

Photosynthesis

2 of 6

2.58

1.4

0.0027

map00860

Porphyrin and chlorophyll metabolism

3 of 58

1.77

1.25

0.0027

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1362409

Mitochondrial iron-sulfur cluster biogenesis

8 of 19

2.68

8.35

2.24e-17

MAP-2395516

Electron transport from NADPH to Ferredoxin

2 of 3

2.88

1.37

0.0033

MAP-1268020

Mitochondrial protein import

3 of 69

1.7

1.06

0.0068

MAP-1430728

Metabolism

9 of 2335

0.64

0.49

0.0033

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990221

L-cysteine desulfurase complex

3 of 9

2.58

2.14

0.00011

GOCC:0009341

Beta-galactosidase complex

2 of 6

2.58

1.1

0.0097

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