A0A443I6G0 protein (Byssochlamys spectabilis)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

A0A443I6G0

25S rRNA adenine-N(1) methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA; Belongs to the BMT2 family. (296 aa)

Predicted Functional Partners:

A0A443HPW5

0.877

A0A443HYX7

0.836

A0A443I0D7

0.836

A0A443HIU5

0.830

A0A443I695

0.804

A0A443HZK7

0.800

A0A443I290

0.800

A0A443I5Z1

0.791

A0A443HKU5

0.788

A0A443HQ73

0.772

Your Current Organism:

Byssochlamys spectabilis

NCBI taxonomy Id: 264951
Other names: ATCC 90900, B. spectabilis, Byssochlamys spectabilis (Udagawa & Shoji Suzuki) Houbraken & Samson 2008, CBS 101075, FRR 5219, JCM 12815, Pacilomyces variotii, Paecilomyces spectabilis, Paecilomyces variotii, Paecilomyces variotti, Paecilomyces vatiotii, Talaromyces spectabilis

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A443HIU5	A0A443HKU5	Ribosomal protein; Belongs to the universal ribosomal protein uL1 family.	Putative 60S ribosomal protein L2.	0.999
A0A443HIU5	A0A443HPW5	Ribosomal protein; Belongs to the universal ribosomal protein uL1 family.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	0.847
A0A443HIU5	A0A443HQ73	Ribosomal protein; Belongs to the universal ribosomal protein uL1 family.	Putative rRNA biogenesis protein RRP5.	0.990
A0A443HIU5	A0A443HYX7	Ribosomal protein; Belongs to the universal ribosomal protein uL1 family.	Putative mitochondrial translation initiation factor IF-2.	0.974
A0A443HIU5	A0A443HZK7	Ribosomal protein; Belongs to the universal ribosomal protein uL1 family.	50S ribosomal protein L3.	0.996
A0A443HIU5	A0A443I0D7	Ribosomal protein; Belongs to the universal ribosomal protein uL1 family.	Translation initiation factor 2.	0.971
A0A443HIU5	A0A443I290	Ribosomal protein; Belongs to the universal ribosomal protein uL1 family.	Ribosomal protein L3-domain-containing protein; Belongs to the universal ribosomal protein uL3 family.	0.999
A0A443HIU5	A0A443I5Z1	Ribosomal protein; Belongs to the universal ribosomal protein uL1 family.	50S ribosomal protein L2.	0.994
A0A443HIU5	A0A443I695	Ribosomal protein; Belongs to the universal ribosomal protein uL1 family.	Ribosomal protein L23/L15e core domain-containing protein.	0.999
A0A443HIU5	A0A443I6G0	Ribosomal protein; Belongs to the universal ribosomal protein uL1 family.	25S rRNA adenine-N(1) methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA; Belongs to the BMT2 family.	0.830
A0A443HKU5	A0A443HIU5	Putative 60S ribosomal protein L2.	Ribosomal protein; Belongs to the universal ribosomal protein uL1 family.	0.999
A0A443HKU5	A0A443HPW5	Putative 60S ribosomal protein L2.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	0.893
A0A443HKU5	A0A443HQ73	Putative 60S ribosomal protein L2.	Putative rRNA biogenesis protein RRP5.	0.983
A0A443HKU5	A0A443HYX7	Putative 60S ribosomal protein L2.	Putative mitochondrial translation initiation factor IF-2.	0.984
A0A443HKU5	A0A443HZK7	Putative 60S ribosomal protein L2.	50S ribosomal protein L3.	0.980
A0A443HKU5	A0A443I0D7	Putative 60S ribosomal protein L2.	Translation initiation factor 2.	0.954
A0A443HKU5	A0A443I290	Putative 60S ribosomal protein L2.	Ribosomal protein L3-domain-containing protein; Belongs to the universal ribosomal protein uL3 family.	0.999
A0A443HKU5	A0A443I695	Putative 60S ribosomal protein L2.	Ribosomal protein L23/L15e core domain-containing protein.	0.999
A0A443HKU5	A0A443I6G0	Putative 60S ribosomal protein L2.	25S rRNA adenine-N(1) methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA; Belongs to the BMT2 family.	0.788
A0A443HPW5	A0A443HIU5	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	Ribosomal protein; Belongs to the universal ribosomal protein uL1 family.	0.847

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Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.962

expected number of edges:

16

PPI enrichment p-value:

3.98e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046426

Negative regulation of receptor signaling pathway via JAK-STAT

4 of 11

2.76

3.32

6.97e-07

GO:0016032

Viral process

4 of 40

2.2

2.46

1.37e-05

GO:0006271

DNA strand elongation involved in DNA replication

3 of 18

2.42

1.93

0.00024

GO:0006270

DNA replication initiation

3 of 25

2.28

1.79

0.00040

GO:0044786

Cell cycle DNA replication

3 of 27

2.24

1.78

0.00041

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031462

Cul2-RING ubiquitin ligase complex

4 of 10

2.8

3.78

9.49e-08

GO:0070449

Elongin complex

3 of 8

2.77

2.69

1.13e-05

GO:0071162

CMG complex

3 of 11

2.63

2.55

1.87e-05

GO:0031461

cullin-RING ubiquitin ligase complex

5 of 122

1.81

2.34

4.72e-06

GO:0000228

Nuclear chromosome

4 of 130

1.68

1.7

0.00015

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7345

Cul2-RING ubiquitin ligase complex, and Cul5-RING ubiquitin ligase complex

5 of 10

2.9

5.12

2.88e-10

CL:7347

VCB complex, and Elongin-C

4 of 5

3.1

4.52

5.31e-09

CL:7219

Neddylation

6 of 81

2.07

3.79

4.12e-09

CL:6178

DNA replication initiation, and Activation of the pre-replicative complex

4 of 33

2.28

2.9

1.94e-06

CL:6187

MCM N-terminal domain, and Cdc6, C-terminal

2 of 5

2.8

1.52

0.0017

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04120

Ubiquitin mediated proteolysis

5 of 212

1.57

1.85

2.14e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1234176

Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha

5 of 55

2.16

3.19

2.67e-07

MAP-1234174

Cellular response to hypoxia

5 of 59

2.12

3.16

2.67e-07

MAP-69239

Synthesis of DNA

4 of 131

1.68

1.54

0.00039

MAP-69306

DNA Replication

4 of 142

1.65

1.52

0.00040

MAP-8951664

Neddylation

5 of 271

1.46

0.00020

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070449

Elongin complex

2 of 7

2.65

0.95

0.0188

GOCC:0042555

MCM complex

2 of 13

2.38

0.85

0.0274

GOCC:0000151

Ubiquitin ligase complex

3 of 147

1.51

0.65

0.0476

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0347

Helicase

2 of 36

1.94

0.73

0.0431

KW-0235

DNA replication

2 of 28

2.05

0.73

0.0431

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039948

Elongin-C

2 of 2

3.2

1.12

0.0095

IPR001232

S-phase kinase-associated protein 1-like

2 of 3

3.02

1.12

0.0095

IPR041562

MCM, AAA-lid domain

2 of 7

2.65

1.01

0.0147

IPR033762

MCM OB domain

2 of 8

2.59

1.01

0.0147

IPR027925

MCM N-terminal domain

2 of 6

2.72

1.01

0.0147

(more ...)

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