STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
edd6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (624 aa)    
Predicted Functional Partners:
Mfla_0760
TIGRFAM: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; PRIAM: 2-dehydro-3-deoxyphosphogluconate aldolase; PFAM: KDPG and KHG aldolase; KEGG: cvi:CV0143 2-dehydro-3-deoxy-phosphogluconate aldolase; COGs: COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase category=G.
 
 0.999
pgl
6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
 
 
 0.970
Mfla_2599
6-phosphogluconate dehydrogenase (decarboxylating); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
   
 0.918
Mfla_0918
TIGRFAM: 6-phosphogluconate dehydrogenase, decarboxylating; PFAM: 6-phosphogluconate dehydrogenase domain protein; 6-phosphogluconate dehydrogenase, NAD-binding; KEGG: dra:DR1595 6-phosphogluconate dehydrogenase; COGs: COG1023 6-phosphogluconate dehydrogenase category=G.
     
 0.905
zwf
Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone.
 
  
 0.853
Mfla_1061
TIGRFAM: glucose-6-phosphate 1-dehydrogenase; PRIAM: Glucose-6-phosphate 1-dehydrogenase; PFAM: glucose-6-phosphate dehydrogenase; KEGG: noc:Noc_0772 glucose-6-phosphate 1-dehydrogenase; COGs: COG0364 Glucose-6-phosphate 1-dehydrogenase category=G.
 
  
 0.853
Mfla_2734
PRIAM: Glutamate synthase (NADPH); PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: atc:AGR_C_235 hypothetical protein; COGs: COG0069 Glutamate synthase domain 2 category=E.
  
  
 0.850
leuC
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
  
  
 0.839
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.818
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
  
  
 0.766
Your Current Organism:
Methylobacillus flagellatus
NCBI taxonomy Id: 265072
Other names: M. flagellatus KT, Methylobacillus flagellatus KT, Methylobacillus flagellatus str. KT, Methylobacillus flagellatus strain KT
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