Mfla_0763 protein (Methylobacillus flagellatus)

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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Databases

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[Homology]

Score

Mfla_0763

Glycosyl transferase, group 1. (364 aa)

Predicted Functional Partners:

Mfla_0765

0.904

Mfla_0758

0.881

Mfla_0762

0.793

Mfla_0761

0.773

Mfla_0764

0.766

Mfla_0754

0.700

Mfla_0757

0.656

Mfla_2028

0.611

Mfla_0755

0.592

Mfla_1398

0.547

Your Current Organism:

Methylobacillus flagellatus

NCBI taxonomy Id: 265072
Other names: M. flagellatus KT, Methylobacillus flagellatus KT, Methylobacillus flagellatus str. KT, Methylobacillus flagellatus strain KT

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
Mfla_0754	Mfla_0755	Glycosyl transferase, group 1.	Lipopolysaccharide kinase; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core; Belongs to the protein kinase superfamily. KdkA/rfaP family.	0.999
Mfla_0754	Mfla_0757	Glycosyl transferase, group 1.	Conserved hypothetical protein.	0.917
Mfla_0754	Mfla_0758	Glycosyl transferase, group 1.	Carbamoyltransferase.	0.911
Mfla_0754	Mfla_0763	Glycosyl transferase, group 1.	Glycosyl transferase, group 1.	0.700
Mfla_0754	Mfla_0765	Glycosyl transferase, group 1.	Conserved hypothetical protein.	0.622
Mfla_0754	Mfla_1398	Glycosyl transferase, group 1.	Hypothetical protein.	0.553
Mfla_0754	Mfla_2028	Glycosyl transferase, group 1.	Sugar transferase.	0.543
Mfla_0755	Mfla_0754	Lipopolysaccharide kinase; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core; Belongs to the protein kinase superfamily. KdkA/rfaP family.	Glycosyl transferase, group 1.	0.999
Mfla_0755	Mfla_0757	Lipopolysaccharide kinase; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core; Belongs to the protein kinase superfamily. KdkA/rfaP family.	Conserved hypothetical protein.	0.918
Mfla_0755	Mfla_0758	Lipopolysaccharide kinase; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core; Belongs to the protein kinase superfamily. KdkA/rfaP family.	Carbamoyltransferase.	0.915
Mfla_0755	Mfla_0763	Lipopolysaccharide kinase; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core; Belongs to the protein kinase superfamily. KdkA/rfaP family.	Glycosyl transferase, group 1.	0.592
Mfla_0755	Mfla_0765	Lipopolysaccharide kinase; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core; Belongs to the protein kinase superfamily. KdkA/rfaP family.	Conserved hypothetical protein.	0.656
Mfla_0755	Mfla_1398	Lipopolysaccharide kinase; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core; Belongs to the protein kinase superfamily. KdkA/rfaP family.	Hypothetical protein.	0.674
Mfla_0755	Mfla_2028	Lipopolysaccharide kinase; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core; Belongs to the protein kinase superfamily. KdkA/rfaP family.	Sugar transferase.	0.543
Mfla_0757	Mfla_0754	Conserved hypothetical protein.	Glycosyl transferase, group 1.	0.917
Mfla_0757	Mfla_0755	Conserved hypothetical protein.	Lipopolysaccharide kinase; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core; Belongs to the protein kinase superfamily. KdkA/rfaP family.	0.918
Mfla_0757	Mfla_0758	Conserved hypothetical protein.	Carbamoyltransferase.	0.952
Mfla_0757	Mfla_0762	Conserved hypothetical protein.	Toluene tolerance protein, putative.	0.401
Mfla_0757	Mfla_0763	Conserved hypothetical protein.	Glycosyl transferase, group 1.	0.656
Mfla_0757	Mfla_0765	Conserved hypothetical protein.	Conserved hypothetical protein.	0.716

page 1 of 4

Network Stats

number of nodes:

9

number of edges:

23

average node degree:

5.11

avg. local clustering coefficient:

0.948

expected number of edges:

13

PPI enrichment p-value:

0.00676

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006366

Transcription by RNA polymerase II

10 of 96

2.47

9.23

5.24e-21

GO:0006367

Transcription initiation from RNA polymerase II promoter

5 of 30

2.67

5.11

1.64e-10

GO:0006360

Transcription by RNA polymerase I

4 of 22

2.71

4.11

1.89e-08

GO:0006383

Transcription by RNA polymerase III

4 of 26

2.64

3.96

3.18e-08

GO:0042797

tRNA transcription by RNA polymerase III

2 of 2

3.45

2.26

8.67e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

4 of 32

2.55

3.23

7.72e-07

GO:0003677

DNA binding

7 of 996

1.3

1.59

4.10e-06

GO:0003676

Nucleic acid binding

8 of 1926

1.07

1.16

9.65e-06

GO:0008270

Zinc ion binding

3 of 309

1.44

0.79

0.0201

GO:1901363

Heterocyclic compound binding

9 of 5632

0.65

0.52

0.0014

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016591

RNA polymerase II, holoenzyme

10 of 58

2.69

11.09

1.14e-23

GO:0005665

RNA polymerase II, core complex

7 of 16

3.09

9.4

2.39e-18

GO:0005736

RNA polymerase I complex

4 of 13

2.94

4.85

1.03e-09

GO:0005666

RNA polymerase III complex

4 of 19

2.77

4.5

3.61e-09

GO:0005674

Transcription factor TFIIF complex

2 of 2

3.45

2.55

2.53e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5276

RNA Polymerase II Pre-transcription Events, and Tyrosinase activity

10 of 114

2.39

8.72

2.01e-20

CL:5314

RNA polymerase II, core complex

6 of 8

3.33

8.53

2.20e-16

CL:5286

RNA Polymerase II Pre-transcription Events, and Tyrosinase activity

9 of 104

2.39

8.08

1.04e-18

CL:5412

Mixed, incl. Transcription factor TFIIH core complex, and Transcription factor TFIIF complex

3 of 12

2.85

3.12

1.84e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03020

RNA polymerase

7 of 55

2.55

7.09

4.23e-15

map03022

Basal transcription factors

3 of 268

1.5

0.97

0.0074

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-76042

RNA Polymerase II Transcription Initiation And Promoter Clearance

10 of 56

2.7

11.17

9.59e-24

MAP-75953

RNA Polymerase II Transcription Initiation

10 of 56

2.7

11.17

9.59e-24

MAP-73779

RNA Polymerase II Transcription Pre-Initiation And Promoter Opening

10 of 56

2.7

11.17

9.59e-24

MAP-73776

RNA Polymerase II Promoter Escape

10 of 56

2.7

11.17

9.59e-24

MAP-77075

RNA Pol II CTD phosphorylation and interaction with CE

9 of 43

2.77

10.66

4.32e-22

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

10 of 99

2.45

9.32

2.08e-21

GOCC:0055029

Nuclear DNA-directed RNA polymerase complex

7 of 74

2.43

6.37

5.24e-14

GOCC:0016591

RNA polymerase II, holoenzyme

6 of 49

2.54

5.9

1.81e-12

GOCC:0005665

RNA polymerase II, core complex

3 of 10

2.93

3.31

8.69e-07

GOCC:0031981

Nuclear lumen

7 of 875

1.35

1.84

4.42e-07

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0804

Transcription

4 of 81

2.14

2.67

3.99e-06

KW-0240

DNA-directed RNA polymerase

3 of 25

2.53

2.61

1.26e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR011039

Transcription Factor IIF, Rap30/Rap74, interaction

2 of 2

3.45

1.48

0.0022

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