node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mfla_0439 | folD | Mfla_0439 | Mfla_0073 | PRIAM: Aminomethyltransferase; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr7320 aminomethyltransferase; COGs: COG0404 Glycine cleavage system T protein (aminomethyltransferase) category=E; Belongs to the GcvT family. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.954 |
Mfla_0439 | glyA | Mfla_0439 | Mfla_1917 | PRIAM: Aminomethyltransferase; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr7320 aminomethyltransferase; COGs: COG0404 Glycine cleavage system T protein (aminomethyltransferase) category=E; Belongs to the GcvT family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.995 |
Mfla_0439 | purH | Mfla_0439 | Mfla_0349 | PRIAM: Aminomethyltransferase; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr7320 aminomethyltransferase; COGs: COG0404 Glycine cleavage system T protein (aminomethyltransferase) category=E; Belongs to the GcvT family. | TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PRIAM: Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme; MGS domain protein; KEGG: bma:BMA2356 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) category=F. | 0.929 |
Mfla_0439 | purT | Mfla_0439 | Mfla_1255 | PRIAM: Aminomethyltransferase; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr7320 aminomethyltransferase; COGs: COG0404 Glycine cleavage system T protein (aminomethyltransferase) category=E; Belongs to the GcvT family. | Formate-dependent phosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.908 |
Mfla_0439 | purU | Mfla_0439 | Mfla_2434 | PRIAM: Aminomethyltransferase; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr7320 aminomethyltransferase; COGs: COG0404 Glycine cleavage system T protein (aminomethyltransferase) category=E; Belongs to the GcvT family. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.915 |
Mfla_1031 | folD | Mfla_1031 | Mfla_0073 | TIGRFAM: phosphoribosylformylglycinamidine synthase; PRIAM: Phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: purL; phosphoribosylformylglycinamidine synthase; COGs: COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain category=F. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.799 |
Mfla_1031 | glyA | Mfla_1031 | Mfla_1917 | TIGRFAM: phosphoribosylformylglycinamidine synthase; PRIAM: Phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: purL; phosphoribosylformylglycinamidine synthase; COGs: COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain category=F. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.985 |
Mfla_1031 | purD | Mfla_1031 | Mfla_0348 | TIGRFAM: phosphoribosylformylglycinamidine synthase; PRIAM: Phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: purL; phosphoribosylformylglycinamidine synthase; COGs: COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain category=F. | TIGRFAM: phosphoribosylamine--glycine ligase; PRIAM: Phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp; KEGG: dar:Daro_3668 phosphoribosylglycinamide synthetase; COGs: COG0151 Phosphoribosylamine-glycine ligase category=F; Belongs to the GARS family. | 0.999 |
Mfla_1031 | purE | Mfla_1031 | Mfla_2215 | TIGRFAM: phosphoribosylformylglycinamidine synthase; PRIAM: Phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: purL; phosphoribosylformylglycinamidine synthase; COGs: COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain category=F. | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.999 |
Mfla_1031 | purH | Mfla_1031 | Mfla_0349 | TIGRFAM: phosphoribosylformylglycinamidine synthase; PRIAM: Phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: purL; phosphoribosylformylglycinamidine synthase; COGs: COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain category=F. | TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PRIAM: Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme; MGS domain protein; KEGG: bma:BMA2356 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) category=F. | 0.999 |
Mfla_1031 | purL | Mfla_1031 | Mfla_0887 | TIGRFAM: phosphoribosylformylglycinamidine synthase; PRIAM: Phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: purL; phosphoribosylformylglycinamidine synthase; COGs: COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain category=F. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.999 |
Mfla_1031 | purM | Mfla_1031 | Mfla_0205 | TIGRFAM: phosphoribosylformylglycinamidine synthase; PRIAM: Phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: purL; phosphoribosylformylglycinamidine synthase; COGs: COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain category=F. | TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PRIAM: Phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: rso:RSc2623 phosphoribosylaminoimidazole synthetase; COGs: COG0150 Phosphoribosylaminoimidazole (AIR) synthetase category=F. | 0.999 |
Mfla_1031 | purT | Mfla_1031 | Mfla_1255 | TIGRFAM: phosphoribosylformylglycinamidine synthase; PRIAM: Phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: purL; phosphoribosylformylglycinamidine synthase; COGs: COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain category=F. | Formate-dependent phosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.995 |
Mfla_1031 | purU | Mfla_1031 | Mfla_2434 | TIGRFAM: phosphoribosylformylglycinamidine synthase; PRIAM: Phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: purL; phosphoribosylformylglycinamidine synthase; COGs: COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain category=F. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.550 |
folD | Mfla_0439 | Mfla_0073 | Mfla_0439 | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | PRIAM: Aminomethyltransferase; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr7320 aminomethyltransferase; COGs: COG0404 Glycine cleavage system T protein (aminomethyltransferase) category=E; Belongs to the GcvT family. | 0.954 |
folD | Mfla_1031 | Mfla_0073 | Mfla_1031 | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | TIGRFAM: phosphoribosylformylglycinamidine synthase; PRIAM: Phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: purL; phosphoribosylformylglycinamidine synthase; COGs: COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase synthetase domain category=F. | 0.799 |
folD | glyA | Mfla_0073 | Mfla_1917 | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.985 |
folD | purD | Mfla_0073 | Mfla_0348 | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | TIGRFAM: phosphoribosylamine--glycine ligase; PRIAM: Phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp; KEGG: dar:Daro_3668 phosphoribosylglycinamide synthetase; COGs: COG0151 Phosphoribosylamine-glycine ligase category=F; Belongs to the GARS family. | 0.946 |
folD | purE | Mfla_0073 | Mfla_2215 | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.517 |
folD | purH | Mfla_0073 | Mfla_0349 | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PRIAM: Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme; MGS domain protein; KEGG: bma:BMA2356 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) category=F. | 0.975 |