Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Mfla_2139PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: tbd:Tbd_0854 isocitrate dehydrogenase (NADP); COGs: COG0538 Isocitrate dehydrogenases category=C. (413 aa)    
Predicted Functional Partners:
Mfla_1817
Aconitase; PRIAM: Aconitate hydratase; PFAM: aconitate hydratase domain protein; aconitate hydratase 2; KEGG: noc:Noc_2103 aconitate hydratase; COGs: COG1049 Aconitase B category=C; Belongs to the aconitase/IPM isomerase family.
  
 
 0.986
Mfla_1918
Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
  
 0.968
Mfla_0061
TIGRFAM: citrate synthase I; PRIAM: Citrate (Si)-synthase; PFAM: Citrate synthase; KEGG: tbd:Tbd_1187 citrate synthase I; COGs: COG0372 Citrate synthase category=C; Belongs to the citrate synthase family.
 
 0.967
Mfla_1286
PRIAM: Glutamate dehydrogenase (NADP+); PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal; Glu/Leu/Phe/Val dehydrogenase, dimerisation region; KEGG: eba:ebA5425 glutamate/leucine/phenylalanine/valine dehydrogenase; COGs: COG0334 Glutamate dehydrogenase/leucine dehydrogenase category=E; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 0.916
sucD
succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 
 0.865
sucC
succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.862
Mfla_1456
Hypothetical protein.
  
 0.852
Mfla_1819
TIGRFAM: adenylosuccinate lyase; PRIAM: Adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: tbd:Tbd_0518 adenylosuccinate lyase; COGs: COG0015 Adenylosuccinate lyase category=F; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 
 0.831
Mfla_2076
TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD dependent oxidoreductase; KEGG: bbr:BB2538 dihydrolipoamide dehydrogenase; COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3) component and related enzymes category=C.
   
 0.831
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
  
 0.818
Your Current Organism:
Methylobacillus flagellatus
NCBI taxonomy Id: 265072
Other names: M. flagellatus KT, Methylobacillus flagellatus KT, Methylobacillus flagellatus str. KT, Methylobacillus flagellatus strain KT
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.