STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfla_2449Signal transduction histidine kinase, nitrogen specific, NtrB. (365 aa)    
Predicted Functional Partners:
ntrC
Nitrogen metabolism transcriptional regulator, NtrC, Fis family; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.
 0.994
Mfla_0505
Nitrogen regulatory protein P-II.
  
 0.963
Mfla_1885
Nitrogen regulatory protein P-II (GlnB, GlnK); Belongs to the P(II) protein family.
  
 0.963
Mfla_2656
Multi-sensor hybrid histidine kinase.
 
 
 
 0.780
Mfla_1183
Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s).
 
 
 0.761
Mfla_2587
Multi-sensor hybrid histidine kinase.
 
 
 
0.685
Mfla_0433
Nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
  
 
 0.650
Mfla_2513
Nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
  
 
 0.650
Mfla_2395
Periplasmic sensor signal transduction histidine kinase.
  
 
 
 0.638
glnD
UTP-GlnB (protein PII) uridylyltransferase, GlnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
  
 
 
 0.636
Your Current Organism:
Methylobacillus flagellatus
NCBI taxonomy Id: 265072
Other names: M. flagellatus KT, Methylobacillus flagellatus KT, Methylobacillus flagellatus str. KT, Methylobacillus flagellatus strain KT
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