node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mfl171 | Mfl172 | Mfl171 | Mfl172 | HTH transcriptional regulator merR family. | Dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.593 |
Mfl171 | guaC | Mfl171 | Mfl170 | HTH transcriptional regulator merR family. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.769 |
Mfl172 | Mfl171 | Mfl172 | Mfl171 | Dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | HTH transcriptional regulator merR family. | 0.593 |
Mfl172 | guaC | Mfl172 | Mfl170 | Dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.647 |
Mfl343 | Mfl379 | Mfl343 | Mfl379 | IMP dehydrogenase (Inosine-5'-monophosphate dehydrogenase); Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Xaa-Pro-dipeptidase. | 0.633 |
Mfl343 | Mfl463 | Mfl343 | Mfl463 | IMP dehydrogenase (Inosine-5'-monophosphate dehydrogenase); Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.915 |
Mfl343 | guaA | Mfl343 | Mfl342 | IMP dehydrogenase (Inosine-5'-monophosphate dehydrogenase); Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | GMP synthase (glutamine hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.998 |
Mfl343 | guaC | Mfl343 | Mfl170 | IMP dehydrogenase (Inosine-5'-monophosphate dehydrogenase); Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.900 |
Mfl343 | purA | Mfl343 | Mfl074 | IMP dehydrogenase (Inosine-5'-monophosphate dehydrogenase); Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.942 |
Mfl379 | Mfl343 | Mfl379 | Mfl343 | Xaa-Pro-dipeptidase. | IMP dehydrogenase (Inosine-5'-monophosphate dehydrogenase); Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.633 |
Mfl379 | guaC | Mfl379 | Mfl170 | Xaa-Pro-dipeptidase. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.633 |
Mfl463 | Mfl343 | Mfl463 | Mfl343 | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | IMP dehydrogenase (Inosine-5'-monophosphate dehydrogenase); Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.915 |
Mfl463 | apt | Mfl463 | Mfl276 | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.946 |
Mfl463 | gmk | Mfl463 | Mfl195 | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.932 |
Mfl463 | guaA | Mfl463 | Mfl342 | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | GMP synthase (glutamine hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.961 |
Mfl463 | guaC | Mfl463 | Mfl170 | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.915 |
Mfl463 | purA | Mfl463 | Mfl074 | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.942 |
apt | Mfl463 | Mfl276 | Mfl463 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.946 |
apt | gmk | Mfl276 | Mfl195 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.951 |
apt | guaA | Mfl276 | Mfl342 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase (glutamine hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.987 |