node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mfl193 | nadD | Mfl193 | Mfl373 | Putative NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | deamido-NAD(+) pyrophosphorylase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.949 |
Mfl193 | nadE | Mfl193 | Mfl521 | Putative NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | NH3-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.933 |
Mfl205 | Mfl588 | Mfl205 | Mfl588 | Competence-damage inducible protein; Belongs to the CinA family. | Nicotinic acid phosphoribosyltransferase; Belongs to the NAPRTase family. | 0.931 |
Mfl205 | nadD | Mfl205 | Mfl373 | Competence-damage inducible protein; Belongs to the CinA family. | deamido-NAD(+) pyrophosphorylase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.955 |
Mfl372 | Mfl374 | Mfl372 | Mfl374 | 5'-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase (purine nucleosidase); Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | rRNA methyltransferase; Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily. | 0.773 |
Mfl372 | Mfl375 | Mfl372 | Mfl375 | 5'-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase (purine nucleosidase); Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | Putative xanthosine triphosphatepyrophosphatase. | 0.778 |
Mfl372 | nadD | Mfl372 | Mfl373 | 5'-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase (purine nucleosidase); Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | deamido-NAD(+) pyrophosphorylase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.862 |
Mfl372 | nadE | Mfl372 | Mfl521 | 5'-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase (purine nucleosidase); Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | NH3-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.412 |
Mfl372 | rbfA | Mfl372 | Mfl371 | 5'-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase (purine nucleosidase); Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | Ribosome-binding factor A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. | 0.695 |
Mfl374 | Mfl372 | Mfl374 | Mfl372 | rRNA methyltransferase; Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily. | 5'-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase (purine nucleosidase); Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | 0.773 |
Mfl374 | Mfl375 | Mfl374 | Mfl375 | rRNA methyltransferase; Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily. | Putative xanthosine triphosphatepyrophosphatase. | 0.828 |
Mfl374 | nadD | Mfl374 | Mfl373 | rRNA methyltransferase; Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily. | deamido-NAD(+) pyrophosphorylase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.842 |
Mfl374 | rbfA | Mfl374 | Mfl371 | rRNA methyltransferase; Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily. | Ribosome-binding factor A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. | 0.689 |
Mfl375 | Mfl372 | Mfl375 | Mfl372 | Putative xanthosine triphosphatepyrophosphatase. | 5'-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase (purine nucleosidase); Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | 0.778 |
Mfl375 | Mfl374 | Mfl375 | Mfl374 | Putative xanthosine triphosphatepyrophosphatase. | rRNA methyltransferase; Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily. | 0.828 |
Mfl375 | nadD | Mfl375 | Mfl373 | Putative xanthosine triphosphatepyrophosphatase. | deamido-NAD(+) pyrophosphorylase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.893 |
Mfl375 | rbfA | Mfl375 | Mfl371 | Putative xanthosine triphosphatepyrophosphatase. | Ribosome-binding factor A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. | 0.696 |
Mfl509 | Mfl681 | Mfl509 | Mfl681 | Spermidine/putrescine ABC transporter permease component. | Predicted inner membrane protein. | 0.565 |
Mfl509 | nadD | Mfl509 | Mfl373 | Spermidine/putrescine ABC transporter permease component. | deamido-NAD(+) pyrophosphorylase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.630 |
Mfl588 | Mfl205 | Mfl588 | Mfl205 | Nicotinic acid phosphoribosyltransferase; Belongs to the NAPRTase family. | Competence-damage inducible protein; Belongs to the CinA family. | 0.931 |