STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdhMalate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (325 aa)    
Predicted Functional Partners:
Rxyl_2557
PFAM: Citrate synthase; KEGG: ccr:CC3642 citrate synthase; Belongs to the citrate synthase family.
  
 0.983
Rxyl_1676
KEGG: fra:Francci3_0083 citrate synthase I; TIGRFAM: Citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family.
  
 0.979
Rxyl_2556
Citrate synthase; PFAM: regulatory protein, MerR Citrate synthase; KEGG: bps:BPSL0890 putative citrate synthase.
  
 0.979
fumC
Fumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.978
Rxyl_2748
Fumarase alpha subunit; TIGRFAM: hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha region; PFAM: Fe-S type hydro-lyases tartrate/fumarate alpha region; KEGG: tte:TTE0075 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain.
  
 
 0.962
Rxyl_2749
TIGRFAM: hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; PFAM: Fe-S type hydro-lyases tartrate/fumarate beta region; KEGG: sth:STH2535 fumarate hydratase subunit B.
  
 
 0.962
Rxyl_1110
Malate dehydrogenase (oxaloacetate decarboxylating); PFAM: amino acid-binding ACT malic enzyme-like malic enzyme, NAD-binding; KEGG: sth:STH1319 malate oxidoreductase.
  
 0.958
Rxyl_2041
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
  
 0.950
Rxyl_2064
KEGG: bcz:BCZK1029 malate synthase; TIGRFAM: Malate synthase A; PFAM: malate synthase; Belongs to the malate synthase family.
   
 0.936
Rxyl_1571
PFAM: pyruvate carboxyltransferase Conserved carboxylase region; KEGG: eba:ebA314 putative carboxylase subunit of acetyl-CoA carboxylase-like enzyme.
    
 0.929
Your Current Organism:
Rubrobacter xylanophilus
NCBI taxonomy Id: 266117
Other names: R. xylanophilus DSM 9941, Rubrobacter xylanophilus DSM 9941, Rubrobacter xylanophilus str. DSM 9941, Rubrobacter xylanophilus strain DSM 9941
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