node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rxyl_0835 | Rxyl_1692 | Rxyl_0835 | Rxyl_1692 | Dihydroxyacid dehydratase/phosphogluconate dehydratase-like protein; KEGG: lxx:Lxx13210 dihydroxy-acid dehydratase protein; Belongs to the IlvD/Edd family. | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase-like; KEGG: pab:PAB0892 3-isopropylmalate dehydratase small subunit; Belongs to the LeuD family. | 0.864 |
Rxyl_0835 | Rxyl_2477 | Rxyl_0835 | Rxyl_2477 | Dihydroxyacid dehydratase/phosphogluconate dehydratase-like protein; KEGG: lxx:Lxx13210 dihydroxy-acid dehydratase protein; Belongs to the IlvD/Edd family. | PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: gka:GK0373 acetolactate synthaselarge subunit. | 0.824 |
Rxyl_0835 | Rxyl_3125 | Rxyl_0835 | Rxyl_3125 | Dihydroxyacid dehydratase/phosphogluconate dehydratase-like protein; KEGG: lxx:Lxx13210 dihydroxy-acid dehydratase protein; Belongs to the IlvD/Edd family. | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: det:DET0833 acetolactate synthase, large subunit, biosynthetic type. | 0.884 |
Rxyl_0835 | ilvC | Rxyl_0835 | Rxyl_3127 | Dihydroxyacid dehydratase/phosphogluconate dehydratase-like protein; KEGG: lxx:Lxx13210 dihydroxy-acid dehydratase protein; Belongs to the IlvD/Edd family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.994 |
Rxyl_0835 | ilvD | Rxyl_0835 | Rxyl_1326 | Dihydroxyacid dehydratase/phosphogluconate dehydratase-like protein; KEGG: lxx:Lxx13210 dihydroxy-acid dehydratase protein; Belongs to the IlvD/Edd family. | KEGG: tth:TTC0871 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.929 |
Rxyl_0835 | ilvE | Rxyl_0835 | Rxyl_3128 | Dihydroxyacid dehydratase/phosphogluconate dehydratase-like protein; KEGG: lxx:Lxx13210 dihydroxy-acid dehydratase protein; Belongs to the IlvD/Edd family. | Branched chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.976 |
Rxyl_0835 | leuA | Rxyl_0835 | Rxyl_3129 | Dihydroxyacid dehydratase/phosphogluconate dehydratase-like protein; KEGG: lxx:Lxx13210 dihydroxy-acid dehydratase protein; Belongs to the IlvD/Edd family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.987 |
Rxyl_0835 | leuB | Rxyl_0835 | Rxyl_3130 | Dihydroxyacid dehydratase/phosphogluconate dehydratase-like protein; KEGG: lxx:Lxx13210 dihydroxy-acid dehydratase protein; Belongs to the IlvD/Edd family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.854 |
Rxyl_0835 | leuC2 | Rxyl_0835 | Rxyl_1693 | Dihydroxyacid dehydratase/phosphogluconate dehydratase-like protein; KEGG: lxx:Lxx13210 dihydroxy-acid dehydratase protein; Belongs to the IlvD/Edd family. | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.840 |
Rxyl_0835 | leuD | Rxyl_0835 | Rxyl_0279 | Dihydroxyacid dehydratase/phosphogluconate dehydratase-like protein; KEGG: lxx:Lxx13210 dihydroxy-acid dehydratase protein; Belongs to the IlvD/Edd family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.852 |
Rxyl_1692 | Rxyl_0835 | Rxyl_1692 | Rxyl_0835 | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase-like; KEGG: pab:PAB0892 3-isopropylmalate dehydratase small subunit; Belongs to the LeuD family. | Dihydroxyacid dehydratase/phosphogluconate dehydratase-like protein; KEGG: lxx:Lxx13210 dihydroxy-acid dehydratase protein; Belongs to the IlvD/Edd family. | 0.864 |
Rxyl_1692 | Rxyl_2477 | Rxyl_1692 | Rxyl_2477 | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase-like; KEGG: pab:PAB0892 3-isopropylmalate dehydratase small subunit; Belongs to the LeuD family. | PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: gka:GK0373 acetolactate synthaselarge subunit. | 0.590 |
Rxyl_1692 | Rxyl_3125 | Rxyl_1692 | Rxyl_3125 | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase-like; KEGG: pab:PAB0892 3-isopropylmalate dehydratase small subunit; Belongs to the LeuD family. | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: det:DET0833 acetolactate synthase, large subunit, biosynthetic type. | 0.752 |
Rxyl_1692 | ilvC | Rxyl_1692 | Rxyl_3127 | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase-like; KEGG: pab:PAB0892 3-isopropylmalate dehydratase small subunit; Belongs to the LeuD family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.916 |
Rxyl_1692 | ilvD | Rxyl_1692 | Rxyl_1326 | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase-like; KEGG: pab:PAB0892 3-isopropylmalate dehydratase small subunit; Belongs to the LeuD family. | KEGG: tth:TTC0871 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.860 |
Rxyl_1692 | leuA | Rxyl_1692 | Rxyl_3129 | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase-like; KEGG: pab:PAB0892 3-isopropylmalate dehydratase small subunit; Belongs to the LeuD family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.988 |
Rxyl_1692 | leuB | Rxyl_1692 | Rxyl_3130 | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase-like; KEGG: pab:PAB0892 3-isopropylmalate dehydratase small subunit; Belongs to the LeuD family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.995 |
Rxyl_1692 | leuC2 | Rxyl_1692 | Rxyl_1693 | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase-like; KEGG: pab:PAB0892 3-isopropylmalate dehydratase small subunit; Belongs to the LeuD family. | Homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.999 |
Rxyl_1692 | leuD | Rxyl_1692 | Rxyl_0279 | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase-like; KEGG: pab:PAB0892 3-isopropylmalate dehydratase small subunit; Belongs to the LeuD family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.918 |
Rxyl_2477 | Rxyl_0835 | Rxyl_2477 | Rxyl_0835 | PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: gka:GK0373 acetolactate synthaselarge subunit. | Dihydroxyacid dehydratase/phosphogluconate dehydratase-like protein; KEGG: lxx:Lxx13210 dihydroxy-acid dehydratase protein; Belongs to the IlvD/Edd family. | 0.824 |