| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Rmet_0101 | Rmet_0102 | Rmet_0101 | Rmet_0102 | Putative metallo-beta-lactamase superfamily protein. | Transcriptional regulator, MerR-family. | 0.608 |
| Rmet_0102 | Rmet_0101 | Rmet_0102 | Rmet_0101 | Transcriptional regulator, MerR-family. | Putative metallo-beta-lactamase superfamily protein. | 0.608 |
| Rmet_0102 | Rmet_1823 | Rmet_0102 | Rmet_1823 | Transcriptional regulator, MerR-family. | Conserved hypothetical protein. | 0.597 |
| Rmet_0102 | aceK | Rmet_0102 | Rmet_0104 | Transcriptional regulator, MerR-family. | Isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. | 0.526 |
| Rmet_0102 | dnaJ | Rmet_0102 | Rmet_2921 | Transcriptional regulator, MerR-family. | Chaperone Hsp40, co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interaction [...] | 0.538 |
| Rmet_0102 | evgS | Rmet_0102 | Rmet_2154 | Transcriptional regulator, MerR-family. | Hybrid sensory histidine kinase in two-component regulatory system. | 0.470 |
| Rmet_0102 | ivd1 | Rmet_0102 | Rmet_0103 | Transcriptional regulator, MerR-family. | isovaleryl-CoA dehydrogenase. | 0.598 |
| Rmet_0102 | pbrR2 | Rmet_0102 | Rmet_2302 | Transcriptional regulator, MerR-family. | Transcriptional regulator, MerR-family. | 0.753 |
| Rmet_0102 | pbrR3 | Rmet_0102 | Rmet_3456 | Transcriptional regulator, MerR-family. | Transcriptional regulator, MerR-family. | 0.674 |
| Rmet_0102 | rpoA | Rmet_0102 | Rmet_3291 | Transcriptional regulator, MerR-family. | RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.413 |
| Rmet_0102 | rpoB | Rmet_0102 | Rmet_3334 | Transcriptional regulator, MerR-family. | RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.427 |
| Rmet_1823 | Rmet_0102 | Rmet_1823 | Rmet_0102 | Conserved hypothetical protein. | Transcriptional regulator, MerR-family. | 0.597 |
| Rmet_1823 | evgS | Rmet_1823 | Rmet_2154 | Conserved hypothetical protein. | Hybrid sensory histidine kinase in two-component regulatory system. | 0.534 |
| Rmet_1823 | pbrR2 | Rmet_1823 | Rmet_2302 | Conserved hypothetical protein. | Transcriptional regulator, MerR-family. | 0.538 |
| Rmet_1823 | pbrR3 | Rmet_1823 | Rmet_3456 | Conserved hypothetical protein. | Transcriptional regulator, MerR-family. | 0.538 |
| aceK | Rmet_0102 | Rmet_0104 | Rmet_0102 | Isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. | Transcriptional regulator, MerR-family. | 0.526 |
| aceK | ivd1 | Rmet_0104 | Rmet_0103 | Isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. | isovaleryl-CoA dehydrogenase. | 0.499 |
| dnaJ | Rmet_0102 | Rmet_2921 | Rmet_0102 | Chaperone Hsp40, co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interaction [...] | Transcriptional regulator, MerR-family. | 0.538 |
| dnaJ | evgS | Rmet_2921 | Rmet_2154 | Chaperone Hsp40, co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interaction [...] | Hybrid sensory histidine kinase in two-component regulatory system. | 0.536 |
| dnaJ | pbrR2 | Rmet_2921 | Rmet_2302 | Chaperone Hsp40, co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interaction [...] | Transcriptional regulator, MerR-family. | 0.538 |