STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rmet_0107Short-chain dehydrogenase/reductase SDR. (226 aa)    
Predicted Functional Partners:
Rmet_0108
acyl-CoA dehydrogenase, short-chain specific.
  
  
 0.746
atoB
acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
  
  
 0.664
Rmet_0111
Conserved hypothetical protein; Belongs to the UPF0225 family.
 
    0.638
aceK
Isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
  
    0.570
Rmet_0110
HAD-superfamily hydrolase, subfamily IA.
  
    0.536
can
Carbonic anhydrase.
  
    0.533
Rmet_0109
2-hydroxychromene-2-carboxylate isomerase.
       0.525
Rmet_3467
Putative bifunctional P-450:NADPH-P450 reductase 2 (Includes: Cytochrome P450 102; NADPH--cytochrome P450 reductase).
 
 
 0.451
Rmet_1881
Acyl-CoA thioesterase.
 
  
 0.438
Rmet_0112
Conserved hypothetical signal peptide protein.
  
    0.422
Your Current Organism:
Cupriavidus metallidurans
NCBI taxonomy Id: 266264
Other names: C. metallidurans CH34, Cupriavidus metallidurans CH34, Cupriavidus metallidurans str. CH34, Cupriavidus metallidurans strain CH34, Ralstonia metallidurans CH34, Wautersia metallidurans CH34
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.