STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hoxGHoxG hydrogenase 1, large subunit Uptake hydrogenase large subunit (Hydrogenlyase) (Membrane-bound hydrogenase large subunit) (belongs to CMGI-2). (619 aa)    
Predicted Functional Partners:
hoxZ
hoxZ Probable membrane-bound Ni/Fe-hydrogenase-linked b-type cytochrome (belongs to CMGI-2).
 
 0.999
hoxK
HoxK membrane-bound (NiFe) hydrogenase small subunit (belongs to CMGI-2).
 
 0.999
hoxL
HoxL hydrogenase expression/formation protein hoxL (belongs to CMGI-2).
 
 
 0.950
hoxM
HoxM protein involved in processing of HyaA and HyaB proteins Hydrolase; Nickel Metalloprotease; (belongs to CMGI-2)Protease Absolutely required for hydrogenase activity.
 
 
 0.945
hoxO
HoxO Hydrogenase expression/formation protein hoxO (belongs to CMGI-2); Belongs to the HupG/HyaE family.
 
 
 0.935
hoxQ
HoxQ protein involved in nickel incorporation into hydrogenase-1 proteins(belongs to CMGI-2).
 
  
 0.933
hypA1
HypA1 Hydrogenase nickel incorporation protein hypA (CMGI-2); Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
 
 0.916
hoxT
HoxT putative hydrogenase expression/formation protein (CMGI-2).
 
  
 0.897
hupE
Urease accessory protein; HupE putative membrane-bound hydrogenase component hupE HupE/UreJ protein precursor (modular protein)Uptake hydrogenase (belongs to CMGI-2).
 
  
 0.859
hypA2
Hydrogenase maturation factor HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
 
 0.850
Your Current Organism:
Cupriavidus metallidurans
NCBI taxonomy Id: 266264
Other names: C. metallidurans CH34, Cupriavidus metallidurans CH34, Cupriavidus metallidurans str. CH34, Cupriavidus metallidurans strain CH34, Ralstonia metallidurans CH34, Wautersia metallidurans CH34
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