STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
hypB2GTP hydrolase involved in nickel liganding into hydrogenases. (326 aa)    
Predicted Functional Partners:
hypA2
Hydrogenase maturation factor HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
 
 0.956
hypD2
Protein required for maturation of hydrogenases; Belongs to the HypD family.
 
  
 0.939
hypF2
Carbamoyl phosphate phosphatase and maturation protein for (NiFe) hydrogenases; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
  
 0.935
hypE2
Carbamoyl phosphate phosphatase, hydrogenase 3 maturation protein.
 
  
 0.877
hypA1
HypA1 Hydrogenase nickel incorporation protein hypA (CMGI-2); Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
 
 0.874
hypD1
Protein required for maturation of hydrogenases (CMGI-2); Belongs to the HypD family.
 
  
 0.857
hypC2
Hydrogenase expression/formation protein HypC.
 
  
 0.852
ureF
Urea amidohydrolase (urease) accessory protein UreF; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
  
 
 0.831
hypC1
HypC1 hydrogenase 2 accessory protein (CMGI-2).
 
  
 0.823
hypE1
Carbamoyl phosphate phosphatase, hydrogenase 3 maturation protein (CMGI-2).
 
  
 0.794
Your Current Organism:
Cupriavidus metallidurans
NCBI taxonomy Id: 266264
Other names: C. metallidurans CH34, Cupriavidus metallidurans CH34, Cupriavidus metallidurans str. CH34, Cupriavidus metallidurans strain CH34, Ralstonia metallidurans CH34, Wautersia metallidurans CH34
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