| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ansB | asdA | Rmet_1406 | Rmet_1984 | Isoaspartyl dipeptidase with L-asparaginase activity. | L-Aspartate decarboxylase. | 0.906 |
| ansB | nadB | Rmet_1406 | Rmet_2872 | Isoaspartyl dipeptidase with L-asparaginase activity. | Quinolinate synthase, L-aspartate oxidase (B protein) subunit; Catalyzes the oxidation of L-aspartate to iminoaspartate. | 0.900 |
| ansB | purA | Rmet_1406 | Rmet_2096 | Isoaspartyl dipeptidase with L-asparaginase activity. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.912 |
| ansB | pyrB | Rmet_1406 | Rmet_2740 | Isoaspartyl dipeptidase with L-asparaginase activity. | Aspartate carbamoyltransferase, catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.902 |
| asdA | ansB | Rmet_1984 | Rmet_1406 | L-Aspartate decarboxylase. | Isoaspartyl dipeptidase with L-asparaginase activity. | 0.906 |
| asdA | nadB | Rmet_1984 | Rmet_2872 | L-Aspartate decarboxylase. | Quinolinate synthase, L-aspartate oxidase (B protein) subunit; Catalyzes the oxidation of L-aspartate to iminoaspartate. | 0.909 |
| asdA | purA | Rmet_1984 | Rmet_2096 | L-Aspartate decarboxylase. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.915 |
| asdA | pyrB | Rmet_1984 | Rmet_2740 | L-Aspartate decarboxylase. | Aspartate carbamoyltransferase, catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.903 |
| guaB | hpt | Rmet_1461 | Rmet_3095 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Hypoxanthine phosphoribosyltransferase. | 0.941 |
| guaB | nadB | Rmet_1461 | Rmet_2872 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Quinolinate synthase, L-aspartate oxidase (B protein) subunit; Catalyzes the oxidation of L-aspartate to iminoaspartate. | 0.425 |
| guaB | purA | Rmet_1461 | Rmet_2096 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.990 |
| guaB | purB | Rmet_1461 | Rmet_2956 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.837 |
| guaB | purH | Rmet_1461 | Rmet_0427 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Fused IMP cyclohydrolase; phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.969 |
| guaB | purL | Rmet_1461 | Rmet_1870 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylformyl-glycineamide synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.796 |
| guaB | pyrB | Rmet_1461 | Rmet_2740 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Aspartate carbamoyltransferase, catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.549 |
| guaB | surE | Rmet_1461 | Rmet_2118 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Broad specificity 5'(3')-nucleotidase and polyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.943 |
| hpt | guaB | Rmet_3095 | Rmet_1461 | Hypoxanthine phosphoribosyltransferase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.941 |
| hpt | purA | Rmet_3095 | Rmet_2096 | Hypoxanthine phosphoribosyltransferase. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.941 |
| hpt | purH | Rmet_3095 | Rmet_0427 | Hypoxanthine phosphoribosyltransferase. | Fused IMP cyclohydrolase; phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.934 |
| hpt | purL | Rmet_3095 | Rmet_1870 | Hypoxanthine phosphoribosyltransferase. | Phosphoribosylformyl-glycineamide synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.458 |