| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Rmet_1898 | acs | Rmet_1898 | Rmet_2270 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.932 |
| Rmet_1898 | mmsA | Rmet_1898 | Rmet_0206 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | Methylmalonate-semialdehyde dehydrogenase. | 0.922 |
| Rmet_1898 | prpC | Rmet_1898 | Rmet_1586 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 2-methylcitrate synthase; Belongs to the citrate synthase family. | 0.873 |
| Rmet_3207 | acs | Rmet_3207 | Rmet_2270 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.933 |
| Rmet_3207 | mmsA | Rmet_3207 | Rmet_0206 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | Methylmalonate-semialdehyde dehydrogenase. | 0.916 |
| Rmet_3207 | prpC | Rmet_3207 | Rmet_1586 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 2-methylcitrate synthase; Belongs to the citrate synthase family. | 0.873 |
| aceB | acs | Rmet_1390 | Rmet_2270 | Malate synthase A; Belongs to the malate synthase family. | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.938 |
| aceB | atoB-2 | Rmet_1390 | Rmet_1853 | Malate synthase A; Belongs to the malate synthase family. | acetyl-CoA acetyltransferase / thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.922 |
| aceB | gltA | Rmet_1390 | Rmet_2481 | Malate synthase A; Belongs to the malate synthase family. | Citrate synthase; Belongs to the citrate synthase family. | 0.949 |
| aceB | mmsA | Rmet_1390 | Rmet_0206 | Malate synthase A; Belongs to the malate synthase family. | Methylmalonate-semialdehyde dehydrogenase. | 0.817 |
| aceB | phaA | Rmet_1390 | Rmet_1357 | Malate synthase A; Belongs to the malate synthase family. | Acetyl-CoA acetyltransferase (Acetoacetyl-CoA thiolase); Belongs to the thiolase-like superfamily. Thiolase family. | 0.922 |
| aceB | prpC | Rmet_1390 | Rmet_1586 | Malate synthase A; Belongs to the malate synthase family. | 2-methylcitrate synthase; Belongs to the citrate synthase family. | 0.511 |
| acs | Rmet_1898 | Rmet_2270 | Rmet_1898 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 0.932 |
| acs | Rmet_3207 | Rmet_2270 | Rmet_3207 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 0.933 |
| acs | aceB | Rmet_2270 | Rmet_1390 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Malate synthase A; Belongs to the malate synthase family. | 0.938 |
| acs | atoB-2 | Rmet_2270 | Rmet_1853 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | acetyl-CoA acetyltransferase / thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.929 |
| acs | betB | Rmet_2270 | Rmet_1577 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Betaine-aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 0.932 |
| acs | gltA | Rmet_2270 | Rmet_2481 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Citrate synthase; Belongs to the citrate synthase family. | 0.943 |
| acs | mmsA | Rmet_2270 | Rmet_0206 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Methylmalonate-semialdehyde dehydrogenase. | 0.932 |
| acs | phaA | Rmet_2270 | Rmet_1357 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Acetyl-CoA acetyltransferase (Acetoacetyl-CoA thiolase); Belongs to the thiolase-like superfamily. Thiolase family. | 0.930 |