node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rmet_2398 | aceE | Rmet_2398 | Rmet_1196 | Putative pyridine nucleotide-disulfide oxidoreductase, class I. | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.936 |
Rmet_2398 | aceF | Rmet_2398 | Rmet_1197 | Putative pyridine nucleotide-disulfide oxidoreductase, class I. | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.984 |
Rmet_2398 | gcvH | Rmet_2398 | Rmet_3481 | Putative pyridine nucleotide-disulfide oxidoreductase, class I. | Glycine cleavage complex lipoylprotein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.976 |
Rmet_2398 | gcvP | Rmet_2398 | Rmet_3482 | Putative pyridine nucleotide-disulfide oxidoreductase, class I. | Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.945 |
Rmet_2398 | gcvT-2 | Rmet_2398 | Rmet_3480 | Putative pyridine nucleotide-disulfide oxidoreductase, class I. | Aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. | 0.951 |
Rmet_2398 | glyA | Rmet_2398 | Rmet_2680 | Putative pyridine nucleotide-disulfide oxidoreductase, class I. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.919 |
Rmet_2398 | lpdA | Rmet_2398 | Rmet_1199 | Putative pyridine nucleotide-disulfide oxidoreductase, class I. | Dihydrolipoamide dehydrogenase. | 0.977 |
Rmet_2398 | odhL | Rmet_2398 | Rmet_2048 | Putative pyridine nucleotide-disulfide oxidoreductase, class I. | Dihydrolipoamide dehydrogenase (E3 component). | 0.927 |
Rmet_2398 | sucA | Rmet_2398 | Rmet_2050 | Putative pyridine nucleotide-disulfide oxidoreductase, class I. | 2-oxoglutarate decarboxylase, thiamin-requiring (E1 component). | 0.975 |
Rmet_2398 | sucB | Rmet_2398 | Rmet_2049 | Putative pyridine nucleotide-disulfide oxidoreductase, class I. | Dihydrolipoamide succinyltransferase (E2 component); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | 0.983 |
aceE | Rmet_2398 | Rmet_1196 | Rmet_2398 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Putative pyridine nucleotide-disulfide oxidoreductase, class I. | 0.936 |
aceE | aceF | Rmet_1196 | Rmet_1197 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.996 |
aceE | lpdA | Rmet_1196 | Rmet_1199 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Dihydrolipoamide dehydrogenase. | 0.999 |
aceE | odhL | Rmet_1196 | Rmet_2048 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Dihydrolipoamide dehydrogenase (E3 component). | 0.943 |
aceE | sucA | Rmet_1196 | Rmet_2050 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 2-oxoglutarate decarboxylase, thiamin-requiring (E1 component). | 0.408 |
aceE | sucB | Rmet_1196 | Rmet_2049 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Dihydrolipoamide succinyltransferase (E2 component); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | 0.813 |
aceF | Rmet_2398 | Rmet_1197 | Rmet_2398 | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Putative pyridine nucleotide-disulfide oxidoreductase, class I. | 0.984 |
aceF | aceE | Rmet_1197 | Rmet_1196 | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.996 |
aceF | gcvH | Rmet_1197 | Rmet_3481 | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Glycine cleavage complex lipoylprotein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.712 |
aceF | gcvP | Rmet_1197 | Rmet_3482 | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.564 |