STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
phhAPhenylalanine-4-hydroxylase (PAH) (Phe-4- monooxygenase). (310 aa)    
Predicted Functional Partners:
phhB
Pterin-4-alpha-carbinolamine dehydratase (transcriptional co-activator).
 
 0.996
tyrB
Tyrosine aminotransferase, tyrosine-repressible, PLP-dependent.
  
 
 0.953
pheA
Prephenate dehydratase, Chorismate mutase.
    
 0.933
hisC1
Histidinol-phosphate transaminase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
     
 0.907
hisC
Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
     
 0.907
folA
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
   
 
 0.903
hutH
Histidine ammonia-lyase (Histidase); Has ammonia-lyase and, to a lesser extent, aminomutase activity. Catalyzes the rearrangement of L-tyrosine to R-beta-tyrosine and S-beta-tyrosine. Does not accept L-histidine or L-phenylalanine as substrates; Belongs to the TAL/TAM family.
   
 
 0.830
ubiC
Chorismate pyruvate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family.
     
  0.800
maiA
Maleylacetoacetate isomerase.
 
  
 0.769
mhpD2
2-Oxopent-4-enoate hydratase.
 
  
 0.707
Your Current Organism:
Cupriavidus metallidurans
NCBI taxonomy Id: 266264
Other names: C. metallidurans CH34, Cupriavidus metallidurans CH34, Cupriavidus metallidurans str. CH34, Cupriavidus metallidurans strain CH34, Ralstonia metallidurans CH34, Wautersia metallidurans CH34
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