node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rmet_3560 | Rmet_3561 | Rmet_3560 | Rmet_3561 | Multi-sensor signal transduction histidine kinase. | Conserved hypothetical protein. | 0.950 |
Rmet_3560 | htpX-2 | Rmet_3560 | Rmet_3563 | Multi-sensor signal transduction histidine kinase. | Putative peptidase, heat-shock-like (M48 family); Belongs to the peptidase M48B family. | 0.509 |
Rmet_3560 | sun | Rmet_3560 | Rmet_3562 | Multi-sensor signal transduction histidine kinase. | tRNA and rRNA cytosine-C5-methylase (sun protein); Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.835 |
Rmet_3561 | Rmet_3560 | Rmet_3561 | Rmet_3560 | Conserved hypothetical protein. | Multi-sensor signal transduction histidine kinase. | 0.950 |
Rmet_3561 | htpX-2 | Rmet_3561 | Rmet_3563 | Conserved hypothetical protein. | Putative peptidase, heat-shock-like (M48 family); Belongs to the peptidase M48B family. | 0.509 |
Rmet_3561 | sun | Rmet_3561 | Rmet_3562 | Conserved hypothetical protein. | tRNA and rRNA cytosine-C5-methylase (sun protein); Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.837 |
clpB | ftsH | Rmet_0618 | Rmet_2188 | Chaperone clpB (Heat-shock protein F84.1); Belongs to the ClpA/ClpB family. | Protease, ATP-dependent zinc-metallo; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | 0.454 |
clpB | grpE | Rmet_0618 | Rmet_1004 | Chaperone clpB (Heat-shock protein F84.1); Belongs to the ClpA/ClpB family. | Heat shock/stress protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of AT [...] | 0.737 |
clpB | htpX-2 | Rmet_0618 | Rmet_3563 | Chaperone clpB (Heat-shock protein F84.1); Belongs to the ClpA/ClpB family. | Putative peptidase, heat-shock-like (M48 family); Belongs to the peptidase M48B family. | 0.419 |
clpB | lon | Rmet_0618 | Rmet_1883 | Chaperone clpB (Heat-shock protein F84.1); Belongs to the ClpA/ClpB family. | DNA-binding ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.604 |
clpB-2 | grpE | Rmet_1959 | Rmet_1004 | ATP-dependent Clp protease, ATP-binding subunit ClpB (protein disaggregation chaperone); Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Heat shock/stress protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of AT [...] | 0.780 |
clpB-2 | htpX-2 | Rmet_1959 | Rmet_3563 | ATP-dependent Clp protease, ATP-binding subunit ClpB (protein disaggregation chaperone); Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Putative peptidase, heat-shock-like (M48 family); Belongs to the peptidase M48B family. | 0.473 |
clpB-2 | lon | Rmet_1959 | Rmet_1883 | ATP-dependent Clp protease, ATP-binding subunit ClpB (protein disaggregation chaperone); Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | DNA-binding ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.609 |
fmt | htpX-2 | Rmet_3564 | Rmet_3563 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Putative peptidase, heat-shock-like (M48 family); Belongs to the peptidase M48B family. | 0.496 |
fmt | sun | Rmet_3564 | Rmet_3562 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | tRNA and rRNA cytosine-C5-methylase (sun protein); Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.754 |
ftsH | clpB | Rmet_2188 | Rmet_0618 | Protease, ATP-dependent zinc-metallo; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | Chaperone clpB (Heat-shock protein F84.1); Belongs to the ClpA/ClpB family. | 0.454 |
ftsH | grpE | Rmet_2188 | Rmet_1004 | Protease, ATP-dependent zinc-metallo; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | Heat shock/stress protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of AT [...] | 0.643 |
ftsH | htpX-2 | Rmet_2188 | Rmet_3563 | Protease, ATP-dependent zinc-metallo; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | Putative peptidase, heat-shock-like (M48 family); Belongs to the peptidase M48B family. | 0.566 |
ftsH | kefC | Rmet_2188 | Rmet_3376 | Protease, ATP-dependent zinc-metallo; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | Potassium:proton antiporter; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | 0.523 |
ftsH | lon | Rmet_2188 | Rmet_1883 | Protease, ATP-dependent zinc-metallo; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | DNA-binding ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.707 |