STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sdhAPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (670 aa)    
Predicted Functional Partners:
HY04_07855
Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.999
frdB_2
Fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.999
frdB_1
Fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.998
fumA
Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
 
 0.993
sucC
succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.984
sucD
succinate--CoA ligase; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 0.984
fumC
Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
 
 0.983
puuB
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.940
sad
Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.918
HY04_10630
Fumarylacetoacetase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
  0.907
Your Current Organism:
Chryseobacterium antarcticum
NCBI taxonomy Id: 266748
Other names: C. antarcticum, Chryseobacterium antarcticum (Yi et al. 2005) Kampfer et al. 2009 emend. Hahnke et al. 2016, Chryseobacterium sp. AT1013, DSM 17047, IMSNU 14040, JCM 12381, KCTC 12225, NCTC 13489, Sejongia antarctica, Sejongia antarctica Yi et al. 2005, strain AT1013
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