node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFB68339.1 | SFB89510.1 | SAMN05421876_10119 | SAMN05421876_103276 | ATP-dependent Clp protease adaptor protein ClpS; Belongs to the ClpS family. | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.411 |
SFB68339.1 | clpB | SAMN05421876_10119 | SAMN05421876_11729 | ATP-dependent Clp protease adaptor protein ClpS; Belongs to the ClpS family. | ATP-dependent Clp protease ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.923 |
SFB68339.1 | clpP | SAMN05421876_10119 | SAMN05421876_10690 | ATP-dependent Clp protease adaptor protein ClpS; Belongs to the ClpS family. | ATP-dependent Clp protease, protease subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.834 |
SFB68339.1 | dnaK | SAMN05421876_10119 | SAMN05421876_103302 | ATP-dependent Clp protease adaptor protein ClpS; Belongs to the ClpS family. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.412 |
SFB77833.1 | SFC42539.1 | SAMN05421876_102135 | SAMN05421876_1218 | Uncharacterized membrane protein YhaH, DUF805 family. | Molecular chaperone HtpG. | 0.968 |
SFB77833.1 | clpB | SAMN05421876_102135 | SAMN05421876_11729 | Uncharacterized membrane protein YhaH, DUF805 family. | ATP-dependent Clp protease ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.621 |
SFB77833.1 | clpP | SAMN05421876_102135 | SAMN05421876_10690 | Uncharacterized membrane protein YhaH, DUF805 family. | ATP-dependent Clp protease, protease subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.498 |
SFB77833.1 | dnaK | SAMN05421876_102135 | SAMN05421876_103302 | Uncharacterized membrane protein YhaH, DUF805 family. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.989 |
SFB77833.1 | groS | SAMN05421876_102135 | SAMN05421876_11717 | Uncharacterized membrane protein YhaH, DUF805 family. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.487 |
SFB77833.1 | grpE | SAMN05421876_102135 | SAMN05421876_10853 | Uncharacterized membrane protein YhaH, DUF805 family. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.799 |
SFB77833.1 | lon | SAMN05421876_102135 | SAMN05421876_105124 | Uncharacterized membrane protein YhaH, DUF805 family. | ATP-dependent Lon protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.435 |
SFB89510.1 | SFB68339.1 | SAMN05421876_103276 | SAMN05421876_10119 | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | ATP-dependent Clp protease adaptor protein ClpS; Belongs to the ClpS family. | 0.411 |
SFB89510.1 | clpB | SAMN05421876_103276 | SAMN05421876_11729 | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | ATP-dependent Clp protease ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.634 |
SFB89510.1 | clpP | SAMN05421876_103276 | SAMN05421876_10690 | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | ATP-dependent Clp protease, protease subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.999 |
SFB89510.1 | ftsH | SAMN05421876_103276 | SAMN05421876_102219 | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.880 |
SFB89510.1 | groS | SAMN05421876_103276 | SAMN05421876_11717 | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.580 |
SFB89510.1 | grpE | SAMN05421876_103276 | SAMN05421876_10853 | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.460 |
SFB89510.1 | lon | SAMN05421876_103276 | SAMN05421876_105124 | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | ATP-dependent Lon protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.786 |
SFC42539.1 | SFB77833.1 | SAMN05421876_1218 | SAMN05421876_102135 | Molecular chaperone HtpG. | Uncharacterized membrane protein YhaH, DUF805 family. | 0.968 |
SFC42539.1 | clpB | SAMN05421876_1218 | SAMN05421876_11729 | Molecular chaperone HtpG. | ATP-dependent Clp protease ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.651 |