| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_0328 | Meso_0409 | Meso_0328 | Meso_0409 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: psp:PSPPH_2974 D-isomer specific 2-hydroxyacid dehydrogenase family protein. | 0.420 |
| Meso_0328 | Meso_1922 | Meso_0328 | Meso_1922 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: homoserine dehydrogenase amino acid-binding ACT homoserine dehydrogenase, NAD-binding; KEGG: mlo:mll0934 homoserine dehydrogenase. | 0.948 |
| Meso_0328 | Meso_2580 | Meso_0328 | Meso_2580 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | TIGRFAM: amino acid adenylation domain; PFAM: beta-ketoacyl synthase AMP-dependent synthetase and ligase acyl transferase region condensation domain aminotransferase class-III phosphopantetheine-binding; KEGG: rpa:RPA3339 possible polyketide synthase; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.549 |
| Meso_0328 | Meso_2744 | Meso_0328 | Meso_2744 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: glutamine amidotransferase, class-II glutamate synthase, alpha subunit-like ferredoxin-dependent glutamate synthase glutamate synthase; KEGG: mlo:mll3030 glutamate synthase (NADPH) large chain. | 0.444 |
| Meso_0328 | Meso_3162 | Meso_0328 | Meso_3162 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. | 0.435 |
| Meso_0328 | cysN | Meso_0328 | Meso_0834 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.623 |
| Meso_0408 | Meso_0409 | Meso_0408 | Meso_0409 | PFAM: regulatory proteins, IclR; KEGG: mta:Moth_1780 transcriptional regulator, IclR family. | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: psp:PSPPH_2974 D-isomer specific 2-hydroxyacid dehydrogenase family protein. | 0.538 |
| Meso_0409 | Meso_0328 | Meso_0409 | Meso_0328 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: psp:PSPPH_2974 D-isomer specific 2-hydroxyacid dehydrogenase family protein. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.420 |
| Meso_0409 | Meso_0408 | Meso_0409 | Meso_0408 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: psp:PSPPH_2974 D-isomer specific 2-hydroxyacid dehydrogenase family protein. | PFAM: regulatory proteins, IclR; KEGG: mta:Moth_1780 transcriptional regulator, IclR family. | 0.538 |
| Meso_0409 | Meso_0410 | Meso_0409 | Meso_0410 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: psp:PSPPH_2974 D-isomer specific 2-hydroxyacid dehydrogenase family protein. | PFAM: Xylose isomerase-like TIM barrel; KEGG: ppu:PP2603 hypothetical protein. | 0.536 |
| Meso_0409 | Meso_0411 | Meso_0409 | Meso_0411 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: psp:PSPPH_2974 D-isomer specific 2-hydroxyacid dehydrogenase family protein. | PFAM: NAD-dependent epimerase/dehydratase short-chain dehydrogenase/reductase SDR 3-beta hydroxysteroid dehydrogenase/isomerase; KEGG: bja:bll6359 putative oxidoreductase protein. | 0.531 |
| Meso_0409 | Meso_1385 | Meso_0409 | Meso_1385 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: psp:PSPPH_2974 D-isomer specific 2-hydroxyacid dehydrogenase family protein. | Undecaprenyl pyrophosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.433 |
| Meso_0409 | Meso_1922 | Meso_0409 | Meso_1922 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: psp:PSPPH_2974 D-isomer specific 2-hydroxyacid dehydrogenase family protein. | PFAM: homoserine dehydrogenase amino acid-binding ACT homoserine dehydrogenase, NAD-binding; KEGG: mlo:mll0934 homoserine dehydrogenase. | 0.432 |
| Meso_0409 | Meso_2580 | Meso_0409 | Meso_2580 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: psp:PSPPH_2974 D-isomer specific 2-hydroxyacid dehydrogenase family protein. | TIGRFAM: amino acid adenylation domain; PFAM: beta-ketoacyl synthase AMP-dependent synthetase and ligase acyl transferase region condensation domain aminotransferase class-III phosphopantetheine-binding; KEGG: rpa:RPA3339 possible polyketide synthase; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.471 |
| Meso_0409 | Meso_2744 | Meso_0409 | Meso_2744 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: psp:PSPPH_2974 D-isomer specific 2-hydroxyacid dehydrogenase family protein. | PFAM: glutamine amidotransferase, class-II glutamate synthase, alpha subunit-like ferredoxin-dependent glutamate synthase glutamate synthase; KEGG: mlo:mll3030 glutamate synthase (NADPH) large chain. | 0.458 |
| Meso_0409 | Meso_3162 | Meso_0409 | Meso_3162 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: psp:PSPPH_2974 D-isomer specific 2-hydroxyacid dehydrogenase family protein. | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. | 0.779 |
| Meso_0409 | cysN | Meso_0409 | Meso_0834 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: psp:PSPPH_2974 D-isomer specific 2-hydroxyacid dehydrogenase family protein. | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. | 0.453 |
| Meso_0410 | Meso_0409 | Meso_0410 | Meso_0409 | PFAM: Xylose isomerase-like TIM barrel; KEGG: ppu:PP2603 hypothetical protein. | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: psp:PSPPH_2974 D-isomer specific 2-hydroxyacid dehydrogenase family protein. | 0.536 |
| Meso_0410 | Meso_0411 | Meso_0410 | Meso_0411 | PFAM: Xylose isomerase-like TIM barrel; KEGG: ppu:PP2603 hypothetical protein. | PFAM: NAD-dependent epimerase/dehydratase short-chain dehydrogenase/reductase SDR 3-beta hydroxysteroid dehydrogenase/isomerase; KEGG: bja:bll6359 putative oxidoreductase protein. | 0.671 |
| Meso_0411 | Meso_0409 | Meso_0411 | Meso_0409 | PFAM: NAD-dependent epimerase/dehydratase short-chain dehydrogenase/reductase SDR 3-beta hydroxysteroid dehydrogenase/isomerase; KEGG: bja:bll6359 putative oxidoreductase protein. | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: psp:PSPPH_2974 D-isomer specific 2-hydroxyacid dehydrogenase family protein. | 0.531 |