| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_0097 | Meso_0423 | Meso_0097 | Meso_0423 | dCTP deaminase; PFAM: 2-deoxycytidine 5-triphosphate deaminase; KEGG: bmb:BruAb1_0332 dCTP deaminase. | TIGRFAM: HAD-superfamily subfamily IIA hydrolase like protein HAD-superfamily hydrolase, subfamily IIA; PFAM: Haloacid dehalogenase-like hydrolase; KEGG: bmb:BruAb2_0194 hydrolase, haloacid dehalogenase-like family. | 0.581 |
| Meso_0097 | Meso_3416 | Meso_0097 | Meso_3416 | dCTP deaminase; PFAM: 2-deoxycytidine 5-triphosphate deaminase; KEGG: bmb:BruAb1_0332 dCTP deaminase. | PFAM: protein of unknown function DUF1674; KEGG: sil:SPO3377 hypothetical protein. | 0.753 |
| Meso_0097 | hisG | Meso_0097 | Meso_0419 | dCTP deaminase; PFAM: 2-deoxycytidine 5-triphosphate deaminase; KEGG: bmb:BruAb1_0332 dCTP deaminase. | ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.457 |
| Meso_0097 | hisS | Meso_0097 | Meso_0422 | dCTP deaminase; PFAM: 2-deoxycytidine 5-triphosphate deaminase; KEGG: bmb:BruAb1_0332 dCTP deaminase. | TIGRFAM: histidyl-tRNA synthetase; PFAM: tRNA synthetase, class II (G, H, P and S) Anticodon-binding; KEGG: bms:BRA0187 histidyl-tRNA synthetase. | 0.780 |
| Meso_0421 | Meso_0423 | Meso_0421 | Meso_0423 | KEGG: atu:Atu1660 hypothetical protein. | TIGRFAM: HAD-superfamily subfamily IIA hydrolase like protein HAD-superfamily hydrolase, subfamily IIA; PFAM: Haloacid dehalogenase-like hydrolase; KEGG: bmb:BruAb2_0194 hydrolase, haloacid dehalogenase-like family. | 0.529 |
| Meso_0421 | hisG | Meso_0421 | Meso_0419 | KEGG: atu:Atu1660 hypothetical protein. | ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.773 |
| Meso_0421 | hisS | Meso_0421 | Meso_0422 | KEGG: atu:Atu1660 hypothetical protein. | TIGRFAM: histidyl-tRNA synthetase; PFAM: tRNA synthetase, class II (G, H, P and S) Anticodon-binding; KEGG: bms:BRA0187 histidyl-tRNA synthetase. | 0.773 |
| Meso_0421 | hisZ | Meso_0421 | Meso_0420 | KEGG: atu:Atu1660 hypothetical protein. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.773 |
| Meso_0423 | Meso_0097 | Meso_0423 | Meso_0097 | TIGRFAM: HAD-superfamily subfamily IIA hydrolase like protein HAD-superfamily hydrolase, subfamily IIA; PFAM: Haloacid dehalogenase-like hydrolase; KEGG: bmb:BruAb2_0194 hydrolase, haloacid dehalogenase-like family. | dCTP deaminase; PFAM: 2-deoxycytidine 5-triphosphate deaminase; KEGG: bmb:BruAb1_0332 dCTP deaminase. | 0.581 |
| Meso_0423 | Meso_0421 | Meso_0423 | Meso_0421 | TIGRFAM: HAD-superfamily subfamily IIA hydrolase like protein HAD-superfamily hydrolase, subfamily IIA; PFAM: Haloacid dehalogenase-like hydrolase; KEGG: bmb:BruAb2_0194 hydrolase, haloacid dehalogenase-like family. | KEGG: atu:Atu1660 hypothetical protein. | 0.529 |
| Meso_0423 | Meso_3416 | Meso_0423 | Meso_3416 | TIGRFAM: HAD-superfamily subfamily IIA hydrolase like protein HAD-superfamily hydrolase, subfamily IIA; PFAM: Haloacid dehalogenase-like hydrolase; KEGG: bmb:BruAb2_0194 hydrolase, haloacid dehalogenase-like family. | PFAM: protein of unknown function DUF1674; KEGG: sil:SPO3377 hypothetical protein. | 0.405 |
| Meso_0423 | hisG | Meso_0423 | Meso_0419 | TIGRFAM: HAD-superfamily subfamily IIA hydrolase like protein HAD-superfamily hydrolase, subfamily IIA; PFAM: Haloacid dehalogenase-like hydrolase; KEGG: bmb:BruAb2_0194 hydrolase, haloacid dehalogenase-like family. | ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.603 |
| Meso_0423 | hisS | Meso_0423 | Meso_0422 | TIGRFAM: HAD-superfamily subfamily IIA hydrolase like protein HAD-superfamily hydrolase, subfamily IIA; PFAM: Haloacid dehalogenase-like hydrolase; KEGG: bmb:BruAb2_0194 hydrolase, haloacid dehalogenase-like family. | TIGRFAM: histidyl-tRNA synthetase; PFAM: tRNA synthetase, class II (G, H, P and S) Anticodon-binding; KEGG: bms:BRA0187 histidyl-tRNA synthetase. | 0.782 |
| Meso_0423 | hisZ | Meso_0423 | Meso_0420 | TIGRFAM: HAD-superfamily subfamily IIA hydrolase like protein HAD-superfamily hydrolase, subfamily IIA; PFAM: Haloacid dehalogenase-like hydrolase; KEGG: bmb:BruAb2_0194 hydrolase, haloacid dehalogenase-like family. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.603 |
| Meso_3416 | Meso_0097 | Meso_3416 | Meso_0097 | PFAM: protein of unknown function DUF1674; KEGG: sil:SPO3377 hypothetical protein. | dCTP deaminase; PFAM: 2-deoxycytidine 5-triphosphate deaminase; KEGG: bmb:BruAb1_0332 dCTP deaminase. | 0.753 |
| Meso_3416 | Meso_0423 | Meso_3416 | Meso_0423 | PFAM: protein of unknown function DUF1674; KEGG: sil:SPO3377 hypothetical protein. | TIGRFAM: HAD-superfamily subfamily IIA hydrolase like protein HAD-superfamily hydrolase, subfamily IIA; PFAM: Haloacid dehalogenase-like hydrolase; KEGG: bmb:BruAb2_0194 hydrolase, haloacid dehalogenase-like family. | 0.405 |
| Meso_3416 | hisS | Meso_3416 | Meso_0422 | PFAM: protein of unknown function DUF1674; KEGG: sil:SPO3377 hypothetical protein. | TIGRFAM: histidyl-tRNA synthetase; PFAM: tRNA synthetase, class II (G, H, P and S) Anticodon-binding; KEGG: bms:BRA0187 histidyl-tRNA synthetase. | 0.760 |
| aspS | glyQ | Meso_1122 | Meso_0713 | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. | PFAM: glycyl-tRNA synthetase, alpha subunit; KEGG: mlo:mlr7434 glycyl-tRNA synthetase alpha chain. | 0.681 |
| aspS | hisS | Meso_1122 | Meso_0422 | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. | TIGRFAM: histidyl-tRNA synthetase; PFAM: tRNA synthetase, class II (G, H, P and S) Anticodon-binding; KEGG: bms:BRA0187 histidyl-tRNA synthetase. | 0.848 |
| aspS | thrS | Meso_1122 | Meso_1007 | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. | Ser-tRNA(Thr) hydrolase / threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). | 0.674 |
