| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_0088 | Meso_2580 | Meso_0088 | Meso_2580 | TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase aminotransferase, class I and II aminotransferase class-III; KEGG: bmb:BruAb1_0345 HemA, 5-aminolevulinic acid synthase. | TIGRFAM: amino acid adenylation domain; PFAM: beta-ketoacyl synthase AMP-dependent synthetase and ligase acyl transferase region condensation domain aminotransferase class-III phosphopantetheine-binding; KEGG: rpa:RPA3339 possible polyketide synthase; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.606 |
| Meso_0088 | Meso_2745 | Meso_0088 | Meso_2745 | TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase aminotransferase, class I and II aminotransferase class-III; KEGG: bmb:BruAb1_0345 HemA, 5-aminolevulinic acid synthase. | L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | 0.911 |
| Meso_0088 | kbl | Meso_0088 | Meso_0443 | TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase aminotransferase, class I and II aminotransferase class-III; KEGG: bmb:BruAb1_0345 HemA, 5-aminolevulinic acid synthase. | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.917 |
| Meso_0088 | tdh | Meso_0088 | Meso_0444 | TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase aminotransferase, class I and II aminotransferase class-III; KEGG: bmb:BruAb1_0345 HemA, 5-aminolevulinic acid synthase. | L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.653 |
| Meso_0309 | Meso_0760 | Meso_0309 | Meso_0760 | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mlo:mll7517 threonine synthase. | 0.937 |
| Meso_0309 | Meso_2745 | Meso_0309 | Meso_2745 | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. | L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | 0.913 |
| Meso_0309 | ilvA | Meso_0309 | Meso_1421 | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.924 |
| Meso_0309 | tdh | Meso_0309 | Meso_0444 | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. | L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.906 |
| Meso_0760 | Meso_0309 | Meso_0760 | Meso_0309 | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mlo:mll7517 threonine synthase. | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. | 0.937 |
| Meso_0760 | Meso_2580 | Meso_0760 | Meso_2580 | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mlo:mll7517 threonine synthase. | TIGRFAM: amino acid adenylation domain; PFAM: beta-ketoacyl synthase AMP-dependent synthetase and ligase acyl transferase region condensation domain aminotransferase class-III phosphopantetheine-binding; KEGG: rpa:RPA3339 possible polyketide synthase; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.400 |
| Meso_0760 | Meso_2745 | Meso_0760 | Meso_2745 | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mlo:mll7517 threonine synthase. | L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | 0.927 |
| Meso_0760 | ilvA | Meso_0760 | Meso_1421 | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mlo:mll7517 threonine synthase. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.944 |
| Meso_0760 | tdh | Meso_0760 | Meso_0444 | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mlo:mll7517 threonine synthase. | L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.904 |
| Meso_2580 | Meso_0088 | Meso_2580 | Meso_0088 | TIGRFAM: amino acid adenylation domain; PFAM: beta-ketoacyl synthase AMP-dependent synthetase and ligase acyl transferase region condensation domain aminotransferase class-III phosphopantetheine-binding; KEGG: rpa:RPA3339 possible polyketide synthase; Belongs to the ATP-dependent AMP-binding enzyme family. | TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase aminotransferase, class I and II aminotransferase class-III; KEGG: bmb:BruAb1_0345 HemA, 5-aminolevulinic acid synthase. | 0.606 |
| Meso_2580 | Meso_0760 | Meso_2580 | Meso_0760 | TIGRFAM: amino acid adenylation domain; PFAM: beta-ketoacyl synthase AMP-dependent synthetase and ligase acyl transferase region condensation domain aminotransferase class-III phosphopantetheine-binding; KEGG: rpa:RPA3339 possible polyketide synthase; Belongs to the ATP-dependent AMP-binding enzyme family. | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mlo:mll7517 threonine synthase. | 0.400 |
| Meso_2580 | Meso_2745 | Meso_2580 | Meso_2745 | TIGRFAM: amino acid adenylation domain; PFAM: beta-ketoacyl synthase AMP-dependent synthetase and ligase acyl transferase region condensation domain aminotransferase class-III phosphopantetheine-binding; KEGG: rpa:RPA3339 possible polyketide synthase; Belongs to the ATP-dependent AMP-binding enzyme family. | L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | 0.452 |
| Meso_2580 | kbl | Meso_2580 | Meso_0443 | TIGRFAM: amino acid adenylation domain; PFAM: beta-ketoacyl synthase AMP-dependent synthetase and ligase acyl transferase region condensation domain aminotransferase class-III phosphopantetheine-binding; KEGG: rpa:RPA3339 possible polyketide synthase; Belongs to the ATP-dependent AMP-binding enzyme family. | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.606 |
| Meso_2580 | tdh | Meso_2580 | Meso_0444 | TIGRFAM: amino acid adenylation domain; PFAM: beta-ketoacyl synthase AMP-dependent synthetase and ligase acyl transferase region condensation domain aminotransferase class-III phosphopantetheine-binding; KEGG: rpa:RPA3339 possible polyketide synthase; Belongs to the ATP-dependent AMP-binding enzyme family. | L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.431 |
| Meso_2745 | Meso_0088 | Meso_2745 | Meso_0088 | L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase aminotransferase, class I and II aminotransferase class-III; KEGG: bmb:BruAb1_0345 HemA, 5-aminolevulinic acid synthase. | 0.911 |
| Meso_2745 | Meso_0309 | Meso_2745 | Meso_0309 | L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. | 0.913 |
