| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_0002 | Meso_0753 | Meso_0002 | Meso_0753 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | PFAM: protein of unknown function DUF179; KEGG: mlo:mlr7511 putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | 0.699 |
| Meso_0002 | Meso_1332 | Meso_0002 | Meso_1332 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.706 |
| Meso_0002 | Meso_2703 | Meso_0002 | Meso_2703 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.801 |
| Meso_0002 | thyA | Meso_0002 | Meso_1751 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.754 |
| Meso_0751 | Meso_0752 | Meso_0751 | Meso_0752 | Redoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. | KEGG: mlo:mll7509 hypothetical protein. | 0.674 |
| Meso_0751 | Meso_0753 | Meso_0751 | Meso_0753 | Redoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. | PFAM: protein of unknown function DUF179; KEGG: mlo:mlr7511 putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | 0.511 |
| Meso_0752 | Meso_0751 | Meso_0752 | Meso_0751 | KEGG: mlo:mll7509 hypothetical protein. | Redoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. | 0.674 |
| Meso_0752 | Meso_0753 | Meso_0752 | Meso_0753 | KEGG: mlo:mll7509 hypothetical protein. | PFAM: protein of unknown function DUF179; KEGG: mlo:mlr7511 putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | 0.658 |
| Meso_0753 | Meso_0002 | Meso_0753 | Meso_0002 | PFAM: protein of unknown function DUF179; KEGG: mlo:mlr7511 putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.699 |
| Meso_0753 | Meso_0751 | Meso_0753 | Meso_0751 | PFAM: protein of unknown function DUF179; KEGG: mlo:mlr7511 putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | Redoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. | 0.511 |
| Meso_0753 | Meso_0752 | Meso_0753 | Meso_0752 | PFAM: protein of unknown function DUF179; KEGG: mlo:mlr7511 putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | KEGG: mlo:mll7509 hypothetical protein. | 0.658 |
| Meso_0753 | Meso_1332 | Meso_0753 | Meso_1332 | PFAM: protein of unknown function DUF179; KEGG: mlo:mlr7511 putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.942 |
| Meso_0753 | Meso_1361 | Meso_0753 | Meso_1361 | PFAM: protein of unknown function DUF179; KEGG: mlo:mlr7511 putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | Holliday junction resolvase YqgF; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family. | 0.752 |
| Meso_0753 | Meso_2703 | Meso_0753 | Meso_2703 | PFAM: protein of unknown function DUF179; KEGG: mlo:mlr7511 putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.942 |
| Meso_0753 | Meso_3005 | Meso_0753 | Meso_3005 | PFAM: protein of unknown function DUF179; KEGG: mlo:mlr7511 putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | Glutaredoxin 3; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. | 0.598 |
| Meso_0753 | Meso_3130 | Meso_0753 | Meso_3130 | PFAM: protein of unknown function DUF179; KEGG: mlo:mlr7511 putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | PFAM: regulatory protein GntR, HTH; KEGG: sth:STH2673 GntR family transcriptional regulator. | 0.600 |
| Meso_0753 | secB | Meso_0753 | Meso_3483 | PFAM: protein of unknown function DUF179; KEGG: mlo:mlr7511 putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | Protein translocase subunit secB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. | 0.528 |
| Meso_0753 | thyA | Meso_0753 | Meso_1751 | PFAM: protein of unknown function DUF179; KEGG: mlo:mlr7511 putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.572 |
| Meso_1332 | Meso_0002 | Meso_1332 | Meso_0002 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.706 |
| Meso_1332 | Meso_0753 | Meso_1332 | Meso_0753 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | PFAM: protein of unknown function DUF179; KEGG: mlo:mlr7511 putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | 0.942 |