| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Meso_0309 | Meso_0760 | Meso_0309 | Meso_0760 | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mlo:mll7517 threonine synthase. | 0.937 |
| Meso_0309 | Meso_2745 | Meso_0309 | Meso_2745 | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. | L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | 0.913 |
| Meso_0309 | ilvA | Meso_0309 | Meso_1421 | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.924 |
| Meso_0309 | tdh | Meso_0309 | Meso_0444 | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. | L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.906 |
| Meso_0759 | Meso_0760 | Meso_0759 | Meso_0760 | PFAM: peptidase M16-like; KEGG: mlo:mll7516 processing proteinase; Belongs to the peptidase M16 family. | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mlo:mll7517 threonine synthase. | 0.819 |
| Meso_0760 | Meso_0309 | Meso_0760 | Meso_0309 | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mlo:mll7517 threonine synthase. | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. | 0.937 |
| Meso_0760 | Meso_0759 | Meso_0760 | Meso_0759 | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mlo:mll7517 threonine synthase. | PFAM: peptidase M16-like; KEGG: mlo:mll7516 processing proteinase; Belongs to the peptidase M16 family. | 0.819 |
| Meso_0760 | Meso_1922 | Meso_0760 | Meso_1922 | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mlo:mll7517 threonine synthase. | PFAM: homoserine dehydrogenase amino acid-binding ACT homoserine dehydrogenase, NAD-binding; KEGG: mlo:mll0934 homoserine dehydrogenase. | 0.925 |
| Meso_0760 | Meso_2745 | Meso_0760 | Meso_2745 | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mlo:mll7517 threonine synthase. | L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | 0.927 |
| Meso_0760 | Meso_3001 | Meso_0760 | Meso_3001 | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mlo:mll7517 threonine synthase. | TIGRFAM: aspartate kinase aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase amino acid-binding ACT; KEGG: bmb:BruAb1_1850 aspartate kinase, monofunctional class; Belongs to the aspartokinase family. | 0.822 |
| Meso_0760 | Meso_3162 | Meso_0760 | Meso_3162 | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mlo:mll7517 threonine synthase. | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. | 0.956 |
| Meso_0760 | ilvA | Meso_0760 | Meso_1421 | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mlo:mll7517 threonine synthase. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.944 |
| Meso_0760 | pdxA | Meso_0760 | Meso_1761 | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mlo:mll7517 threonine synthase. | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). | 0.903 |
| Meso_0760 | tdh | Meso_0760 | Meso_0444 | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mlo:mll7517 threonine synthase. | L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.904 |
| Meso_0760 | thrB | Meso_0760 | Meso_0749 | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mlo:mll7517 threonine synthase. | TIGRFAM: homoserine kinase; PFAM: aminoglycoside phosphotransferase; KEGG: mlo:mlr7503 homoserine kinase; Belongs to the pseudomonas-type ThrB family. | 0.922 |
| Meso_1922 | Meso_0760 | Meso_1922 | Meso_0760 | PFAM: homoserine dehydrogenase amino acid-binding ACT homoserine dehydrogenase, NAD-binding; KEGG: mlo:mll0934 homoserine dehydrogenase. | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mlo:mll7517 threonine synthase. | 0.925 |
| Meso_1922 | Meso_3001 | Meso_1922 | Meso_3001 | PFAM: homoserine dehydrogenase amino acid-binding ACT homoserine dehydrogenase, NAD-binding; KEGG: mlo:mll0934 homoserine dehydrogenase. | TIGRFAM: aspartate kinase aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase amino acid-binding ACT; KEGG: bmb:BruAb1_1850 aspartate kinase, monofunctional class; Belongs to the aspartokinase family. | 0.969 |
| Meso_1922 | Meso_3162 | Meso_1922 | Meso_3162 | PFAM: homoserine dehydrogenase amino acid-binding ACT homoserine dehydrogenase, NAD-binding; KEGG: mlo:mll0934 homoserine dehydrogenase. | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. | 0.416 |
| Meso_1922 | thrB | Meso_1922 | Meso_0749 | PFAM: homoserine dehydrogenase amino acid-binding ACT homoserine dehydrogenase, NAD-binding; KEGG: mlo:mll0934 homoserine dehydrogenase. | TIGRFAM: homoserine kinase; PFAM: aminoglycoside phosphotransferase; KEGG: mlo:mlr7503 homoserine kinase; Belongs to the pseudomonas-type ThrB family. | 0.941 |
| Meso_2745 | Meso_0309 | Meso_2745 | Meso_0309 | L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. | 0.913 |
