Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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Meso_0823PFAM: thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate enzyme, central region thiamine pyrophosphate enzyme-like TPP binding region; KEGG: thiamine pyrophosphate-requiring enzyme; Belongs to the TPP enzyme family. (557 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.961
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 0.946
nadX
Aspartate dehydrogenase; Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
 
    0.944
Meso_0822
PFAM: short-chain dehydrogenase/reductase SDR; KEGG: pae:PA3507 short chain dehydrogenase.
 
 
  0.939
ilvA
L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
 
 0.934
Meso_0820
PFAM: alpha/beta hydrolase fold; KEGG: bte:BTH_II1498 hydrolase, alpha/beta fold family.
 
  
  0.930
Meso_0821
PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: sco:SCO6304 oxidoreductase.
 
    0.928
Meso_0309
L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein.
  
 0.923
Meso_1063
Demethylmenaquinone methyltransferase-like protein; KEGG: mka:MK1449 demethylmenaquinone methyltransferase.
     
  0.900
Meso_0825
PFAM: aldehyde dehydrogenase; KEGG: bte:BTH_II1493 aldehyde dehydrogenase family protein; Belongs to the aldehyde dehydrogenase family.
 
  0.890
Your Current Organism:
Chelativorans sp. BNC1
NCBI taxonomy Id: 266779
Other names: C. sp. BNC1, Mesorhizobium sp. BNC1
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